A bstract Aim and objective Mental well-being is one of the most important aspects of health. Life-threatening situations such as diseases affect mental well-being. Mindfulness-based stress reduction (MBSR) program is an effective program for improving well-being. This study aimed to evaluate the effectiveness of MBSR programs on the mental well-being of patients with coronavirus disease-2019 (COVID-19). Materials and methods This randomized controlled trial study was conducted in 2021. We used simple random sampling for recruiting 60 patients with COVID-19 and assigned them to the intervention and control groups. The intervention comprised eight sessions of the MBSR and was performed for the experimental group. The control group received routine postdischarge care. We used a self-report demographic and Ryff's Psychological Well-being Scale to collect data. To analyze the data, descriptive statistics and inferential statistics including Covariance, MANCOVA, and effect coefficient were used. The Significance level was considered lower than 0. 05. We used SPSS version 21 for data management. Results The mean score of mental well-being in the intervention group was 56.76 ± 6.88 in the pretest stage and 80.76 ± 7.53 in the posttest stage, and that in the control group was 54.40 ± 10.31 in the pretest stage and 51.23 ± 10.08 in the posttest stage. There was no significant difference between the two groups before the intervention ( p >0.05) but there was a significant difference ( p <0.05) after the intervention. There was also a significant difference ( p <0.05) between the dimensions of mental well-being before and after the intervention. Conclusion According to our findings, it is recommend to use MBSR program in line with physical treatment for patients with COVID-19. How to cite this article Sadooghiasl A, Ghalenow HR, Mahinfar K, Hashemi SS. Effectiveness of Mindfulness-based Stress Reduction Program in Improving Mental Well-being of Patients with COVID-19: A Randomized Controlled Trial. Indian J Crit Care Med 2022;26(4):439–445.
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