A convergent and highly stereoselctive synthesis of macrolide framework of aldgamycin -M is described. The salient features of the synthesis are the utilization of enzymatic desymmetrization, Crimmin's non-Evans syn aldol reaction, Wittig olefination, Yamaguchi esterification and Ring closing metathesis reaction (RCM).
A highly stereoselective and an efficient approach for studies towards the synthesis of thermolide-6' has been described. The salient features of the synthesis are the utilization of desym-metrization protocol, Barton-McCombie deoxygenation and CÀC bond formation from an aldol reaction.
A highly stereoselective and competent approach for studies towards the synthesis of Portentol has been described. The salient features of the synthesis are the utilization of desymmetrization protocol, Crimmin's non-Evans syn aldol reaction, CÀ C bond formation through an intermolecular Aldol reaction and Barton-McCombie deoxygenation.
A highly stereoselective and an efficient approach for studies towards the synthesis of lepranthin has been described. The key steps involved in this synthesis are desymmetrization protocol, Brown's asymmetric allylation, Wacker oxidation and Corey-Bakshi-Shibata reduction.
Three-component coupling of aldehydes, vinylcyclopropyl carbinols, and nitriles in the presence of 10 mol% TMSOTf at -40 to 0 °C in dichloromethane affords a novel class of (3-oxabicyclo[4.2.0]octanyl)amides in high yields with excellent selectivity, whereas (1-vinylcyclobutyl)methanol provides the corresponding (1-(5-aryltetrahydrofuran-3-yl)cyclobutyl)amides under similar conditions. This is the first report on the synthesis of oxabicycles through a sequential Prins/Wagner/Ritter process.
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