An ornithine‐containing lipid (Orn‐L) or a serine‐containing lipid (Ser‐L) from Flavobacterium meningosepticum exhibited strong mitogenicity for the splenocytes from both LPS‐responder C3H/HeSlc and LPS‐low‐responder C3H/HeJ mice. The potency of the lipoamino acids was the same as that of LPS for responder mice. The lipoamino acids were B‐lymphocyte mitogens. Furthermore, Orn‐L or Ser‐L exhibited strong adjuvanticity. Compared with the adjuvanticity of LPS, the activity of Orn‐L was rather high. Based on these data, together with the previously reported data of macrophage activation, we propose that the lipoamino acids are non‐toxic, potent immunoactivators.
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