C-H, N-H coupling of azole and thiophene derivatives takes place in the presence of a catalytic amount of Cu(OAc) 2 and an additive. The reaction of azoles smoothly occurs with several amines and amides catalyzed by 20 mol% of Cu(OAc) 2-2PPh 3 and 4 equiv. of NaOAc under O 2 or in the presence of Ag 2 CO 3 under N 2. The coupling reaction leads to a facile synthesis of a Nsubstituted analogue of 2,5-diarylthiazole, which shows photoluminescent properties with extended -conjugation. Spectroscopic characteristics of the obtained thiazole derivatives are discussed by measurements of UV-vis absorption and photoluminescent spectra. Under the reaction conditions using Ag 2 CO 3 as an additive and Cu(OAc) 2-2PPh 3 as a catalyst, thiophene derivatives also react with 2-pyrrolidone to undergo C-H, N-H amidation.
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