Uranyl ion catalyses the oligomerization of cytidine-5'-phosphoroimidazolide in aqueous solution, yielding 3'-5'-linked cyclic diand tri-cytidylates preferentially at high catalyst concentration, or 2'-5'linked linear oligocytidylates at lower catalyst concentration. Addition of Ag + affects the uranyl ion-catalysed oligocytidylate formation and alters the product distribution.A series of reactions of activated nucleotides in aqueous solution provides a non-enzymatic model of nucleic acid biosynthesis,' and affords a new attractive synthetic method for oligonu~leotides.~*~ Nucleoside 5'-phosphoroimidazolide, an
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