Objective: Fluorescence visualization devices are screening devices that can be used to examine lesions of the oral mucosa non-invasively. We observed oral squamous cell carcinoma (OSCC) and leukoplakia using the IllumiScan (Shofu, Kyoto, Japan) fluorescence visualization device and examined its usefulness and characteristics.Methods: We investigated 31 OSCC and nine leukoplakia in patients who were examined using the IllumiScan and treated in our department from January 2017 to February 2018. Images taken with the IllumiScan were analyzed using image analysis software. We also examined the lesions using narrowband imaging (NBI). Additionally, the IllumiScan and NBI images and the non-stained areas of iodine staining method (IOM) were visually evaluated.Results: The average luminance of OSCC in the keratinized mucosa was significantly lower than that of OSCC in non-keratinized mucosa. The average luminance of OSCC was significantly lower than that of leukoplakia. Even in keratinized mucosa where IOM is impossible to use, the OSCC lesion exhibited fluorescence visualization loss.Conclusion: The application of the fluorescence visualization device to the oral mucosa may be useful for distinguishing between cancer and normal areas and can be used to detect OSCC in the keratinized mucosa. The use of the IllumiScan in combination with other conventional screening methods may lead to a better diagnosis.
The cores of 164 ferruginous bodies from seven non‐primary asbestos workers were analyzed by the carbon planchet method to elucidate the nature of the core mineral and the relationship between ferruginous body type and the core characteristics. One hundred and sixty‐two cores, except for two talcs, were all amphibole group asbestos. Amosite and anthophyllite fibers were all finer than 0.9 μm and mainly less than 0.5 μm in diameter and had tendency to form type I asbestos bodies. On the other hand, tremolite and actinolite fibers constituted non‐beaded club‐like type II or type IV bodies and tended to have a larger diameter than that of amosite or anthophyllite fibers (p<0.005). These results suggest that the type of asbestos body depends fundamentally on the core diameter (width) rather than the type of asbestos, although the core diameter was correlated with asbestos type. For the analysis and evaluation of ferruginous body cores, which are completely coated, it is necessary to denude the ferruginous coating. This study suggested the usefulness of the carbon planchet method with Dodson's method. ACTA PATHOL JPN 38: 989∼1000, 1988.
We report a case of pigmented nevi with large masses in the maxillary and mandibular gingiva. Case : A 43-year-old man presented with a black spot on the left maxillary and mandibular gingiva since childhood, and a mass formation in the same area from his twenties. He was referred to our hospital in September 2005. After self-interruption of his consultation two times, the patient consulted us again in April 2016 due to augmentation of the masses. The lobular and pigmented masses had smooth surfaces, were irregular, and were elastic hard in the left maxillary and mandibular gingiva. No abnormal bone resorption was revealed by panoramic radiography and CT. A biopsy was performed to confirm the definitive diagnosis under local anesthesia, and a histopathological examination showed intradermal type pigmented nevus. The patient does not wish surgical treatment and is still under observation without specific treatment.
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