Objective
Recent studies have demonstrated the pro‐tumour role of CD36 in multiple cancer types. However, its role has not been well elucidated in oral squamous cell carcinoma (OSCC). Here, we aimed to evaluate the role of CD36 in proliferation and migration of OSCC cells.
Methods
Human OSCC cell lines HSC‐2, HSC‐3, HSC‐4 and Ca9‐22 were assessed for proliferation by staining with the cell proliferation marker Ki‐67. We also assessed migration activity, and the expression of cell adhesion molecules such as E‐cadherin and β‐catenin and platelet‐derived growth factor receptors (PDGFRs) of CD36‐positive cells.
Results
CD36‐positive cells showed increased expression of Ki‐67 and migration activity compared with CD36‐negative cells. Moreover, CD36‐positive cells showed reduced expression of E‐cadherin and β‐catenin, whereas the expression of PDGFRs increased compared with that in CD36‐negative cells.
Conclusions
Our results strongly suggest that CD36 has an important role in facilitating the proliferation and migration activity of OSCC cells, indicating its usefulness in the diagnosis of high‐grade tumour and targeted therapy of oral cancer.
Intraosseous mucoepidermoid carcinoma of the jaw is a rare lesion that has been suggested to originate from the odontogenic epithelium. We report an unusual case of central mucoepidermoid carcinoma in an 18‐year‐old Japanese man with an odontogenic cyst.
Bone sarcoidosis is uncommon, and involvement of the temporomandibular joint is exceptionally rare. We report an unusual case of mandibular condyle sarcoidosis in a 51‐year‐old Japanese woman that manifested as a temporomandibular joint arthritis. The patient was referred for a chief complaint of a painful temporomandibular joint and was initially diagnosed with temporomandibular joint arthritis. However, a more detailed examination revealed bone sarcoidosis in the mandibular condyle and the progression of preexisting cardiac sarcoidosis. Oral steroid treatment (tapered from 50 mg/day to 5 mg/day) appears to have been successful over a 1‐year follow‐up.
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