The reaction of ribonucleosides with di-t-butylsilyl diester such as dinitrate, diperchlorate and ditriflate in DMF gave selectively 3′,5′-O-(di-t-butylsilanediyl)ribonucleosides in high yield. The conformation analysis by 1H NMR spectroscopy and X-ray crystallography showed that the product has a restricted conformation analogous to that observable in 3′,5′-cyclic nucleotides.
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