Epiregulin (EPR), a novel member of epidermal growth factor (EGF) family, is a ligand for ErbB-1 and ErbB-4 receptors. The binding a⁄nity of EPR for the receptors is lower than those of other EGF-family ligands. The solution structure of EPR was determined using two-dimensional nuclear magnetic resonance spectroscopy. The secondary structure in the C-terminal domain of EPR is di¡erent from other EGFfamily ligands because of the lack of hydrogen bonds. The structural di¡erence in the C-terminal domain may provide an explanation for the reduced binding a⁄nity of EPR to the ErbB receptors.
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