We examined the in vivo effect of 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3- one (Phx) on Meth A carcinoma cells transplanted into BALB/c mice, in terms of both antitumor activity and side effects. Phx, which was synthesized by the reaction of 2-amino-5-methylphenol with bovine hemolysates, was administered i.p. at doses of 1 and 5 mg/kg to BALB/c mice transplanted with Meth A tumor cells. Phx exerted a strong antitumor activity to Meth A tumor growing in the mice as 5-fluorouracil (5-FU) did. The antitumor activity of Phx at the dose of 5 mg/kg was comparable to that of 5-FU at the dose of 7.8 mg/kg. In contrast, unlike 5-FU, Phx did not cause leukopenia while showing a strong antitumor activity. The compound also produced little changes in body weight and no wasting of mice developed. These results show that Phx has strong anti-tumor activity, but exerts lower side effects and suggest that Phx is available for therapeutic purposes in the future.
Occasionally, we have experienced cases of patients with mild articulating pain who have been introduced to opioids. We considered the possibility that physician assessment alone might be insuf cient. We developed and examined the usefulness of a system that helps pharmacists perform a pain assessment prior to consultation and suggest prescriptions for analgesics.From March 1, 2020 to December 31, 2020, the number of prescription suggestions and the rate at which they were adopted were investigated in patients who were instructed before opioid introduction. The number of patients instructed was 226, whereas the number of prescription suggestions was 231, with an adoption rate of 98.3%. The 23 patients who did not use opioids showed signi cantly improved mean pain scores, from a median NRS of 3 -2 (P = 0.0123), with the most intense pain decreasing from a median NRS of 7 -5 (P = 0.0154). We believe that pain assessment before opioid induction facilitated the selection of an appropriate analgesic. However, among the nine patients who were instructed after opioid introduction, two expressed minor pain. We believe that the pharmacist's prescription suggestion, which is tailored to the patientʼs life background and general condition, promoted the selection of an appropriate analgesic.In conclusion, pharmacists should evaluate pain and prescription suggestions before introducing opioids as a strategy to support medical treatment and promote appropriate opioid use, thereby suggesting their active utilization in clinical practice throughout Japan.
Six cases of scrub typhus (tsutsugamushi disease) were reported to the Shizuoka Prefecture Hamamatsu City public health center during the seven years from 2001 to 2007. The content of the clinical record of the five cases were investigated. High serum titers of antibody to Gilliam-type Orientia tsutsugamushi were detected by immunofluorescense assay in most of these patients. Fever, rash, headache and relative bradycardia seen at a high frequency. On peripheral blood smear examination, atypical lymphocytes were detected in 3 cases. Serum electrolyte examination revealed hyponatremia in 4 (80%) patients; SIADH was suspected in one of these cases. All the patients improved promptly following start of therapy with intravenous or oral minocycline.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.