The INTERSPEECH 2018 Computational Paralinguistics Challenge addresses four different problems for the first time in a research competition under well-defined conditions: In the Atypical Affect Sub-Challenge, four basic emotions annotated in the speech of handicapped subjects have to be classified; in the Self-Assessed Affect Sub-Challenge, valence scores given by the speakers themselves are used for a three-class classification problem; in the Crying Sub-Challenge, three types of infant vocalisations have to be told apart; and in the Heart Beats Sub-Challenge, three different types of heart beats have to be determined. We describe the Sub-Challenges, their conditions, and baseline feature extraction and classifiers, which include data-learnt (supervised) feature representations by end-to-end learning, the 'usual' ComParE and BoAW features, and deep unsupervised representation learning using the AUDEEP toolkit for the first time in the challenge series.

Highlights► Our study provides new insights into the pre-regressional development of RTT. ► The pre-regression period should not be considered asymptomatic. ► Peculiarities in speech-language development are potential red flags for RTT.

Purpose of ReviewSubstantial research exists focusing on the various aspects and domains of early human development. However, there is a clear blind spot in early postnatal development when dealing with neurodevelopmental disorders, especially those that manifest themselves clinically only in late infancy or even in childhood.Recent FindingsThis early developmental period may represent an important timeframe to study these disorders but has historically received far less research attention. We believe that only a comprehensive interdisciplinary approach will enable us to detect and delineate specific parameters for specific neurodevelopmental disorders at a very early age to improve early detection/diagnosis, enable prospective studies and eventually facilitate randomised trials of early intervention.SummaryIn this article, we propose a dynamic framework for characterising neurofunctional biomarkers associated with specific disorders in the development of infants and children. We have named this automated detection ‘Fingerprint Model’, suggesting one possible approach to accurately and early identify neurodevelopmental disorders.

ABBREVIATIONSPSV Preserved speech variant RTT Rett syndrome AIM Our aim was to contribute new findings related to the pre-regressional verbal development of females with a variant of Rett syndrome (RTT) as the loss of spoken language is one of the key clinical features of RTT, and it would be of particular interest to study the early speech-language development of females who are considered to have preserved some speech-language abilities.METHOD We analysed 461 minutes of audio-video recordings containing play situations and the daily routines of six females (aged 7 to 24 months; mean birthweight 3057g, SD 195g) with the preserved speech variant (PSV) of RTT. All videos were recorded by parents and analysed retrospectively after the diagnosis PSV was made.RESULTS From the age of 7 months onwards, we observed two types of vocalizations, appearing intermittently: (1) apparently normal sequences; and (2) atypical (i.e. inhalatory, pressed, or high-pitched crying-like) vocalizations. Some participants failed to reach the milestone of canonical babbling. We observed a limited phonological and lexical complexity and a restricted compositional variability. Volubility was reduced during the whole period under observation. Hand stereotypies with simultaneous atypical vocalizations appeared only during the second year of life. INTERPRETATIONThe intermittent character of normal versus abnormal verbal behaviours might contribute to an early identification of children with a possible genetic mutation, and provides evidence that speech-language functions are abnormal from the very beginning.Rett syndrome (RTT, MIM 312750), a profoundly disabling neurodevelopmental disorder that predominantly occurs in females, is mainly caused by mutations in the gene MECP2 for the methyl-CpG-binding protein 2 (Xq28).1 It is assumed that MeCP2, a regulator of neuronal activity-dependent synaptic maturation, plays a central role in postnatal brain development. Disruption of MeCP2 affects a wide range of neurodevelopmental functions such as cognitive processes, purposeful hand use, and communicative abilities.2 The pathogenesis of RTT is characterized by a four-stage trajectory, the second of which is the regression period, in which the clinical signs become more prominent.1 The trajectory can be observed in females with classic RTT as well as in other variants of RTT, of which the so-called preserved speech variant (PSV) or Zappella variant (Z-RTT) has a more benign overall pathogenesis, including better manual and speech-language abilities. 1,3,4 Females with PSV have the same staging and a number of the same symptoms as in classic RTT (e.g. the characteristic hand stereotypies) but usually show no general growth failure or deceleration of head growth; epilepsy and hyperventilation are rare.3-5 Furthermore, individuals with PSV show a postregressional improvement in hand use; language abilities may be regained or preserved. Lexicon size and syntactic complexity are reported to increase slowly, but are usually accompanied by features such as e...

We review literature identifying an association between motor abnormality in the first 5 months of infancy and later diagnosis of autism spectrum disorder (ASD) or Rett syndrome (RTT). The assessment of the quality of early spontaneous movements (also known as the assessment of general movements; GMs) is a diagnostic tool that has repeatedly proven to be valuable in detecting early markers for neurodevelopmental disorders. Even though the rate of occurrence of abnormal GMs is exceedingly high in infants later diagnosed with ASD, we endorse further studies using this method either based on family videos or its prospective implementation in high-risk sibling studies to evaluate the power of GM assessment as one potential marker for early maldevelopment in this cohort.

We investigated the early socio-communicative development of individuals with fragile X syndrome (FXS) by undertaking a retrospective analysis of family videos. Videos were analyzed to identify existing communicative forms and functions. Analyses were undertaken on seven children who were later diagnosed with FXS. The children were filmed when they were 9-12 months old and before being diagnosed. Fourteen different communicative forms and six different communicative functions were observed. All participants were observed to express the functions of 'Attention to self' and 'Answering', but none indicated 'Requesting action', 'Requesting information', 'Choice making', or 'Imitating'. Results suggest that children with FXS may have a limited range of communicative forms and functions when they are from 9 to 12 months of age. However, further research is necessary to gain a specific developmental profile of socio-communicative forms and functions in FXS.

Rett syndrome (RTT) is a severe neurological disorder characterized by a developmental regression in motor and speech-language domains. There is, however, limited research on socio-communicative development of affected children before the onset of regression. We analyzed audio-video recordings made by parents of six 9- to 12-month old girls later diagnosed with typical RTT, applying the Inventory of Potential Communicative Acts (IPCA) to identify early communicative forms and functions. Each girl used at least one communicative form (e.g., body movement, eye gaze, or vocalizations) to gain attention and answer, but none were observed to make choices or request information. Varying numbers of children were observed to perform other communicative functions according to the IPCA including social convention, rejecting or requesting an object. Non-verbal forms (e.g., reaching, moving closer, eye contact, smiling) were more common than non-linguistic verbal forms (e.g., unspecified vocalizations, pleasure vocalizations, crying). (Pre-)linguistic verbal forms (e.g., canonical or variegated babbling, proto-words) were not used for communicative purposes. These data suggest that atypical developmental patterns in the socio-communicative domain are evident prior to regression in young individuals later diagnosed with RTT.

There is no evidence that the occurrence of occasional isolated fidgety bursts indicates a milder type of CP.