Key Clinical MessageAcquired factor VIII inhibitors can be a rare cause of extensive intramuscular bleeding requiring fasciotomy. The subsequent postoperative period requires close monitoring due to high risk of fatal blood loss.AbstractAcquired factor VIII inhibitors are a rare cause of often extensive bleeding and subsequently large hematomas. This disorder's overall mortality can reach 38%, largely due to immunosuppression and subsequent infections or an underlying cause such as malignancy. The patient in this case study presented with a hematoma and extensive ecchymosis of the hand and forearm, which continued to progress, precipitating compartment syndrome of the hand and forearm and ultimately requiring fasciotomy. The combination of factors led to significant blood loss in the postoperative period requiring major fluid resuscitation and intensive care unit (ICU) level care. Due to this disorder's rarity and overall mortality, we present this case report with a literature review for management of acquired hemophilia in the setting of urgent fasciotomy.
Chromosome 4q Deletion Syndrome (4QDS) is a rare chromosomal deletion
that presents with various congenital defects that could affect
anesthetic management. We present a patient with known 4QDS who
underwent successful general anesthetic induction, tracheal intubation,
and subsequently, bilateral quadratus lumborum nerve blocks, during
laparoscopic inguinal hernia repair surgery.
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