A new method is presented for measuring swelling or rat paw edema in inflammation induced by carrageenin injection. This technique is compared to other widely used ones. A spring-loaded dial indicator produces results that are accurate, precise and reproducible. It is recommended for investigators seeking the advantages of a noninvasive, low cost, rapid method quantifying the swelling of inflammation.
Injections of alpha-1-acid-glycoprotein along with urate crystals induced less footpad swelling than that caused by injections of urate crystals alone. This anti-inflammatory action of acid-glycoprotein is considered to add further support to the hypothesis that perturbations in acute phase proteins are protective.
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