10.5%), cardiovascular (8.7%), dermatologic (6.3%), and carcinogenic (6.3%) issues. Among the 87products for which the timing of marketing was available, the median time on the marker was 5.4 years with about one-third withdrawn within the first two years. It is hoped that the current review will stimulate other future research into this important topic. However, due to the intrinsic limitations of the descriptive analysis design, our observations are subject to the availability of data in the public domain. Readers are cautioned to be objective and careful when approaching data of this nature in order not to misinterpret the results due to potential data gaps.