Highlights
Oral cancer is highly stratified by tumor as opposed to host characteristics.
Host peripheral blood data can impact prognosis in oral cancer.
Autoimmune diseases are macroscopic reflection of host immune dysregulation.
A score was created known as AI score to depict host status.
AI score was useful as a prognostic tool in oral cancer and should be more widely investigated.
Background and Objectives
Recent literature has highlighted the role of the host in the prognosis of oral squamous cell carcinoma (OSCC). In this study, we retrospectively examined the impact of autoimmune (AI) disorders as an aspect of the host status on survival outcomes in OSCC patients.
Methods
From a departmental database of OSCC patients (n = 1369), 123 patients with an AI disorder were identified. AI and no‐AI groups were compared for survival outcomes.
Results
There were no significant differences in survival between groups for overall survival, disease‐specific survival, local, regional, and distant recurrence‐free probabilities. However, survival and recurrence‐free probabilities were poorer in the AI group versus the no AI group.
Conclusion
Patients with AI disease trended towards worse outcomes. This suggests immune dysregulation in these patients may impact oncologic outcomes.
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