The glycosaminoglycan hyaluronic acid (also called hyaluronan or hyaluronate and abbreviated as HA) is a major component of the extracellular matrix (ECM) of skin and plays an important role in the metabolism of both the epidermis and dermis. Hyaluronan is responsible for hydration, nutrient exchange, and protects against free radical damage via a multitude of signaling pathways. It is also involved in basic biologic processes such as cell differentiation and motility. An overview is provided here that provides recent information, bringing up-to-date advances in matrix biology relevant for dermatology and skin care, with a particular emphasis on skin moisture. HyaluronanHyaluronan is a highly anionic molecule. At the body's pH, it is one of the most highly charged molecules in biology, which provides HA with some of its unique qualities. A massive cloud of water surrounds the molecule in an attempt to neutralize the charge. It is this particular quality which provides the hydrating functions of HA, with the simultaneous ability to expand tissues and to open spaces for cell movement.Extrinsic aging in the human skin, compared with photo-protected skin is associated with alterations in the expression of HA and its metabolizing enzymes, both the hyaluronidases and the HA synthase complex of enzymes [ 58 ] , as described below. It is clear that the "dried" appearance of aging skin is intimately associated with changes in apparent levels and types of HA deposition, dependent on changes in controls of its underlying metabolism.Hyaluronan is involved in multiple aspects of skin biology, responsible not only for skin hydration but also for nutrient exchange, tissue homeostasis, repair processes, protection against free radical damage, cell differentiation, and cell motility. Native and formulated preparations of HA, applied exogenously, help skin regain elasticity, turgor, as well as moisture. Understanding HA metabolism may provide clues for reversing some of the processes that lead to skin aging, loss of moisture, and wrinkling. Hyaluronan in SkinThere are numerous reports of decreased amounts of HA in aging skin. These observations are based on histochemical stains, such as Alcian blue, and affi nity histochemistry with the
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