A daily PT program appears feasible and may improve overall development in young children with cerebral palsy in GMFCS level V.

The proposed project tests the principle that frequency of rehabilitation is an important regulator of therapeutic response in infants. Methods: We will randomize 75 infants with cerebral palsy, 6-24 months of age and GMFCS III-V (higher severity), to determine the short term and long-term effects of 3 dosing protocols consisting of an identical number of 2 hour sessions of the same motor learning based therapy applied over a different total number of calendar weeks. Results and Conclusions: The results will inform clinicians, families, and scientists about dosing and will provide needed recommendations for frequency of rehabilitation in order to optimize motor function and development of young children with cerebral palsy.