956RESUMO: "Efeito da erva-mate (Ilex paraguariensis A. St.-Hil., Aquifoliaceae) sobre o colesterol, triacilglicerídeos e glucose em ratos Wistar com dieta alimentar suplementada com lipídeos e glicídeos" Ilex paraguariensis A. St.-Hil., Aquifoliaceae, é uma espécie nativa das regiões subtropicais e temperadas da América do Sul, usada em bebidas por infusão como chá, chimarrão e tererê. Para verificar os efeitos fisiológicos que a I. paraguariensis pode causar sobre o metabolismo de lipídeos e glicídeos em ratos Wistar, após a ingestão de chá de erva-mate, analisou-se quatro grupos experimentais: Grupo Lipídeo Controle (receberam água e dieta hiperlipídica); Grupo Lipídeo Ingestão (extrato de I. paraguariensis e dieta hiperlipídica); Grupo Glicídeo Controle (receberam água e dieta hiperglicídica); e Grupo Glicídeo Ingestão (extrato de I. paraguariensis e dieta hiperglicídica). Os animais receberam a dieta por 60 dias, de acordo com o grupo que pertenciam, sendo pesados semanalmente. Após esse período, foram avaliadas as concentrações de colesterol, glicose e triacilglicerídeos sanguíneos, e ainda, peso da gordura visceral. Os dados foram analisados estatísticamente. O nível de significância aceito foi p<0,05. Os resultados mostraram que a ingestão de erva-mate atua sobre o peso corpóreo, gordura visceral e taxas de glucose, colesterol e triacilglicerídeos plasmáticos. Unitermos: Ilex paraguariensis, metabolismo de lipídios, metabolismo de glicídios.ABSTRACT: Ilex paraguariensis A. St.-Hil., Aquifoliaceae, is a species native to the subtropical and temperate regions of South America, used in beverages prepared by infusion such as teas, chimarrão and tererê. To investigate the physiological effects of I. paraguariensis on the metabolism of fats and sugars in Wistar rats, following the ingestion of erva-mate tea, four experimental groups were constructed: Lipid Control Group (receiving water and high-fat diet); Lipid Tea Group (extract of I. paraguariensis and high-fat diet); the Sugar Control Group (water and high-sugar diet); and Sugar Tea Group (extract of I. paraguariensis and high-sugar diet). The animals received their particular diet for 60 days, and were weighed weekly. After this period, the plasma concentrations of cholesterol, glucose and triacylglycerides were determined, together with the weight of visceral fat. The data were subjected to statistical analysis with a significance level of p<0.05. The results show that the ingestion of erva-mate affected body weight, visceral fat and plasma glucose, cholesterol and triacylglyceride levels. Keywords:Ilex paraguariensis, fat metabolism, sugar metabolism.Revista Brasileira de Farmacognosia Brazilian Journal of Pharmacognosy 20(6): 956-961, Dez. 2010 Article
Modifications in life-style and/or pharmacotherapies contribute to weight loss and ameliorate the metabolic profile of diet-induced obese humans and rodents. Since these strategies fail to treat hypothalamic obesity, we have assessed the possible mechanisms by which duodenal-jejunal bypass (DJB) surgery regulates hepatic lipid metabolism and the morphophysiology of pancreatic islets, in hypothalamic obese (HyO) rats. During the first 5 days of life, male Wistar rats received subcutaneous injections of monosodium glutamate (4 g/kg body weight, HyO group), or saline (CTL). At 90 days of age, HyO rats were randomly subjected to DJB (HyO DJB group) or sham surgery (HyO Sham group). HyO Sham rats were morbidly obese, insulin resistant, hypertriglyceridemic and displayed higher serum concentrations of non-esterified fatty acids (NEFA) and hepatic triglyceride (TG). These effects were associated with higher expressions of the lipogenic genes and fatty acid synthase (FASN) protein content in the liver. Furthermore, hepatic genes involved in β-oxidation and TG export were down-regulated in HyO rats. In addition, these rats exhibited hyperinsulinemia, β-cell hypersecretion, a higher percentage of islets and β-cell area/pancreas section, and enhanced nuclear content of Ki67 protein in islet-cells. At 2 months after DJB surgery, serum concentrations of TG and NEFA, but not hepatic TG accumulation and gene and protein expressions, were normalized in HyO rats. Insulin release and Ki67 positive cells were also normalized in HyO DJB islets. In conclusion, DJB decreased islet-cell proliferation, normalized insulinemia, and ameliorated insulin sensitivity and plasma lipid profile, independently of changes in hepatic metabolism.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.