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Propargyl aldehyde complexes, (RC⋮CCHO)Co2(CO)6 (1a−c; R = Ph, Me, H), undergo pinacol coupling with a variety of reductants, exclusively giving syn (dl)-diacetylenic diol complexes 2a−c. The X-ray structures of 2a and 2c have been determined. The free diol syn-PhC⋮C−CH(OH)CH(OH)−C⋮CPh (4a) is obtained efficiently from its cobalt complex 2a upon treatment with (NH4)2Ce(NO3)6.

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Breast cancer metastases exhibit many different genetic alterations, including copy number amplifications. Using publicly available datasets, we identify copy number amplifications in metastatic breast tumor samples and using our organoid-based metastasis assays, and we validate FGFR1 is amplified in collectively migrating organoids. Because the heterogeneity of breast tumors is increasingly becoming relevant to clinical practice, we demonstrate our organoid method captures genetic heterogeneity of individual tumors.

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