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Background: A case study is proposed to empirically test and discuss the eye-tracking status-quo hardware capabilities and limitations of an off-the-shelf virtual reality (VR) headset with embedded eye-tracking for at-home ready-to-go online usability in ophthalmology applications. Methods: The eye-tracking status-quo data quality of the HTC Vive Pro Eye is investigated with novel testing specific to objective online VR perimetry. Testing was done across a wide visual field of the head-mounted-display’s (HMD) screen and in two different moving conditions. A new automatic and low-cost Raspberry Pi system is introduced for VR temporal precision testing for assessing the usability of the HTC Vive Pro Eye as an online assistance tool for visual loss. Results: The target position on the screen and head movement evidenced limitations of the eye-tracker capabilities as a perimetry assessment tool. Temporal precision testing showed the system’s latency of 58.1 milliseconds (ms), evidencing its good potential usage as a ready-to-go online assistance tool for visual loss. Conclusions: The test of the eye-tracking data quality provides novel analysis useful for testing upcoming VR headsets with embedded eye-tracking and opens discussion regarding expanding future introduction of these HMDs into patients’ homes for low-vision clinical usability.

The sustained component of visual attention lowers the perceptual threshold of stimuli located at the attended region. Attentional performance is not equal for all eccentric positions, leading to variations in perception. The location of the preferred retinal locus (PRL) for fixation might be influenced by these attentional variations. This study investigated the relation between the placement of sustained attention and the location of a developed PRL using simulations of central scotoma. Thirteen normally sighted subjects participated in the study. Monocular sustained attention was measured in discrete eccentric locations of the visual field using the dominant eye. Subsequently, a six degrees macular scotoma was simulated and PRL training was performed during eight ten-minutes blocks of trials. After training, every subject developed a PRL. Subjects with high attentional capabilities in the lower hemifield generally developed PRLs in the lower hemifield (n=10), subjects with high attentional capabilities in the upper hemifield developed PRLs in the upper hemifield (n=2) and one subject with similar attentional capabilities in the upper and lower hemifield developed the PRL on the upper hemifield. Analyzed individually, the results showed that 70% of the subjects had a PRL location in the hemifield where high attentional performance was achieved. These results suggest that attentional capabilities can be used as a predictor for the development of the PRL and are of significance for low vision rehabilitation and for the development of new PRL training procedures, with the option for a preventive attentional training in early macular disease to develop a favorable PRL.

SummaryPressures for survival drive sensory circuit adaption to a species’ habitat, making it essential to statistically characterise natural scenes. Mice, a prominent visual system model, are dichromatic with enhanced sensitivity to green and UV. Their visual environment, however, is rarely considered. Here, we built a UV-green camera to record footage from mouse habitats. We found chromatic contrast to greatly diverge in the upper but not the lower visual field, an environmental difference that may underlie the species’ superior colour discrimination in the upper visual field. Moreover, training an autoencoder on upper but not lower visual field scenes was sufficient for the emergence of colour-opponent filters. Furthermore, the upper visual field was biased towards dark UV contrasts, paralleled by more light-offset-sensitive cells in the ventral retina. Finally, footage recorded at twilight suggests that UV promotes aerial predator detection. Our findings support that natural scene statistics shaped early visual processing in evolution.Lead contactFurther information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Thomas Euler (thomas.euler@cin.uni-tuebingen.de)

A number of virtual reality head-mounted displays (HMDs) with integrated eye trackers have recently become commercially available. If their eye tracking latency is low and reliable enough for gaze-contingent rendering, this may open up many interesting opportunities for researchers. We measured eye tracking latencies for the Fove-0, the Varjo VR-1, and the High Tech Computer Corporation (HTC) Vive Pro Eye using simultaneous electrooculography measurements. We determined the time from the occurrence of an eye position change to its availability as a data sample from the eye tracker (delay) and the time from an eye position change to the earliest possible change of the display content (latency). For each test and each device, participants performed 60 saccades between two targets 20° of visual angle apart. The targets were continuously visible in the HMD, and the saccades were instructed by an auditory cue. Data collection and eye tracking calibration were done using the recommended scripts for each device in Unity3D. The Vive Pro Eye was recorded twice, once using the SteamVR SDK and once using the Tobii XR SDK. Our results show clear differences between the HMDs. Delays ranged from 15 ms to 52 ms, and the latencies ranged from 45 ms to 81 ms. The Fove-0 appears to be the fastest device and best suited for gaze-contingent rendering.

Patients with central vision loss obtain visual information by fixating on an object eccentrically with a preferred retinal locus of fixation (PRL). Patients do not always choose the most efficient PRL position, and as a consequence, visual performance is not always fully exploited. This study investigates whether PRLs can be induced by applying systematic stimulus relocations. The PRL was trained using a central scotoma simulation in 15 healthy subjects. They performed different visual tasks during four sessions, after which their reading performance was evaluated. In five subjects the stimulus was relocated to the left hemifield whenever a saccade would place the stimulus on the opposite hemifield. In five different subjects the relocation was inversed: The stimulus was located in the right hemifield. The relocation was 7.5° of visual angle and it was applied horizontally. Five additional subjects naturally chose the PRL location. They were used as the control group to evaluate the development of a PRL. After training, subjects performed visual search tasks on static stimuli. Evaluation after training showed that systematic stimulus relocations can be used to influence the development of the PRL. These results might be significant for the development of training strategies for the visually impaired.

Image skew is one of the prominent distortions that exist in optical elements, such as in spectacle lenses. The present study evaluates adaptation to image skew in dynamic natural images. Moreover, the cortical levels involved in skew coding were probed using retinal specificity of skew adaptation aftereffects. Left and right skewed natural image sequences were shown to observers as adapting stimuli. The point of subjective equality (PSE), i.e., the skew amplitude in simple geometrical patterns that is perceived to be unskewed, was used to quantify the aftereffect of each adapting skew direction. The PSE, in a two-alternative forced choice paradigm, shifted toward the adapting skew direction. Moreover, significant adaptation aftereffects were obtained not only at adapted, but also at non-adapted retinal locations during fixation. Skew adaptation information was transferred partially to non-adapted retinal locations. Thus, adaptation to skewed natural scenes induces coordinated plasticity in lower and higher cortical areas of the visual pathway.

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