The origin of high-energy cosmic rays, atomic nuclei that continuously impact Earth’s atmosphere, is unknown. Because of deflection by interstellar magnetic fields, cosmic rays produced within the Milky Way arrive at Earth from random directions. However, cosmic rays interact with matter near their sources and during propagation, which produces high-energy neutrinos. We searched for neutrino emission using machine learning techniques applied to 10 years of data from the IceCube Neutrino Observatory. By comparing diffuse emission models to a background-only hypothesis, we identified neutrino emission from the Galactic plane at the 4.5σ level of significance. The signal is consistent with diffuse emission of neutrinos from the Milky Way but could also arise from a population of unresolved point sources.

For neuroblastoma, the most common extracranial tumour of childhood, identification of new biomarkers and potential therapeutic targets is mandatory to improve risk stratification and survival rates. MicroRNAs are deregulated in most cancers, including neuroblastoma. In this study, we analysed 430 miRNAs in 69 neuroblastomas by stem-loop RT-qPCR. Prediction of event-free survival (EFS) with support vector machines (SVM) and actual survival times with Cox regression-based models (CASPAR) were highly accurate and were independently validated. SVM-accuracy for prediction of EFS was 88.7% (95% CI: 88.5-88.8%). For CASPAR-based predictions, 5y-EFS probability was 0.19% (95% CI: 0-38%) in the CASPAR-predicted short survival group compared with 0.78% (95%CI: 64-93%) in the CASPAR-predicted long survival group. Both classifiers were validated on an independent test set yielding accuracies of 94.74% (SVM) and 5y-EFS probabilities as 0.25 (95% CI: 0.0-0.55) for short versus 1 6 0.0 for long survival (CASPAR), respectively. Amplification of the MYCN oncogene was highly correlated with deregulation of miRNA expression. In addition, 37 miRNAs correlated with TrkA expression, a marker of excellent outcome, and 6 miRNAs further analysed in vitro were regulated upon TrkA transfection, suggesting a functional relationship. Expression of the most significant TrkA-correlated miRNA, miR-542-5p, also discriminated between local and metastatic disease and was inversely correlated with MYCN amplification and event-free survival. We conclude that neuroblastoma patient outcome prediction using miRNA expression is feasible and effective. Studies testing miRNA-based predictors in comparison to and in combination with mRNA and aCGH information should be initiated. Specific miRNAs (e.g., miR-542-5p) might be important in neuroblastoma tumour biology, and qualify as potential therapeutic targets.Relapse or progression of advanced stage neuroblastoma (NB), the most common extracranial solid tumour of childhood, represents a major treatment challenge in paediatric oncology. Almost one third of all children with advanced stage NB is incurable, and NB accounts for approximately 15% of all childhood cancer deaths. Neuroblastoma is clinically heterogeneous. Tumours of patients with favourable disease may undergo spontaneous regression or differentiation even without therapy. In contrast, patients with unfavourable NB die despite intensive therapy. Favourable tumours are most often localised, stage 1 or 2 tumours, and unfavourable are most often stage 4, metastasised tumours. Stage 4 tumours are metastasised tumours in patients under 1 year of age, which often undergo spontaneous regression with no or minimal therapy. The tumour biology of unfavourable NB is characterised by MYCN amplification, low expression of the TrkA receptor tyrosine kinase and distinct chromosomal aberrations (reviewed in Refs. 1 and 2). Survival rates of patients with unfavourable NB can only be improved by a better understanding of the molecular pathogenesis of NB. This may...

Abstract. Today, many private households as well as broadcasting or film companies own large collections of digital music plays. These are time series that differ from, e.g., weather reports or stocks market data. The task is normally that of classification, not prediction of the next value or recognizing a shape or motif. New methods for extracting features that allow to classify audio data have been developed. However, the development of appropriate feature extraction methods is a tedious effort, particularly because every new classification task requires tailoring the feature set anew. This paper presents a unifying framework for feature extraction from value series. Operators of this framework can be combined to feature extraction methods automatically, using a genetic programming approach. The construction of features is guided by the performance of the learning classifier which uses the features. Our approach to automatic feature extraction requires a balance between the completeness of the methods on one side and the tractability of searching for appropriate methods on the other side. In this paper, some theoretical considerations illustrate the trade-off. After the feature extraction, a second process learns a classifier from the transformed data. The practical use of the methods is shown by two types of experiments: classification of genres and classification according to user preferences.

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We present the development and application of a generic analysis scheme for the measurement of neutrino spectra with the IceCube detector. This scheme is based on regularized unfolding, preceded by an event selection which uses a Minimum Redundancy Maximum Relevance algorithm to select the relevant variables and a random forest for the classification of events. The analysis has been developed using IceCube data from the 59-string configuration of the detector. 27,771 neutrino candidates were detected in 346 days of livetime. A rejection of 99.9999 % of the atmospheric muon background is achieved. The energy spectrum of the atmospheric neutrino flux is obtained using the TRUEE unfolding program. The unfolded spectrum of atmospheric muon neutrinos covers an energy range from 100 GeV to 1 PeV. Compared to the previous measurement using the detector in the 40-string configuration, the analysis presented here, extends the upper end of the atmospheric neutrino spectrum by more than a factor of two, reaching an energy region that has not been previously accessed by spectral measurements.