Objectives-The MATTER and CRASH-2 studies demonstrate Tranexamic Acid (TXA) reduces mortality in patients with traumatic hemorrhage. However, their results, conducted in foreign countries and US military soldiers provoke concerns over generalizability to civilian trauma patients in the United States. We report the evaluation of patient outcomes and transfusion requirements following treatment with TXA by a civilian air medical program. Methods-We conducted a retrospective chart review of trauma patients transported by air service to a level one trauma center. For the purposes of intervention evaluation patients meeting this criterion for the two years (2012-2014) prior to therapy implementation were compared to patients treated during the two-year study period (2014-2016). Goals were to evaluate morbidity, mortality, transfusion requirements and length of stay.
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