Two years of concomitant teriparatide and denosumab therapy increases BMD more than therapy with either medication alone and more than has been reported with any current therapy. The combination of these agents may prove to be an important treatment option in patients at high risk of fracture.
Denosumab, but not alendronate, fully inhibits the ability of high-dose teriparatide to increase bone resorption acutely. These results suggest that combining denosumab with a more potent anabolic stimulus may result in greater separation between bone resorption and formation and hence greater increases in bone mass.
One-to-one computing has emerged as a controversial framework for integrating technology in education. The Cambridge Friends School XO laptop pilot program is a collaboration between the Digital Literacy Project (DigiLit), a non-profit and Harvard College student organization, and the Cambridge Friends School (CFS), an independent K-8 school. This chapter will examine both positive and negative features of the program, as well as a model for implementation of similar programs. DigiLit introduced low-cost XO laptops to two grade levels and designed laptop-based lesson plans. The author also investigated the XO’s effects on collaborative behavior, finding that laptops influenced mobility and sharing of information during group activities. As part of the pilot, students tested new software and completed a survey about the design of an open-source spreadsheet program. The partnership between DigiLit and CFS has provided a platform for researching child-computer interaction and for developing a laptop-based curriculum.
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