2006Carboxylic acids Q 0420Synthesis and Activity of Small Molecule GPR40 Agonists. -A variety of novel compounds, e.g. (VI) and (VII), that activate GPR40 at low nanomolar concentrations, is identified. (VI) behaves as a potent, full agonist at the GPR40 receptor with a pEC50 = 7.91. The acid itself is not critical for activity but elicits a higher agonistic response than that observed with carboxamide replacements (some yields not given).-(GARRIDO, D. M.; CORBETT, D. F.; DWORNIK, K. A.; GOETZ, A. S.; LITTLETON, T. R.; MCKEOWN, S. C.; MILLS, W. Y.; SMALLEY, T. L. J.; BRISCOE, C. P.; PEAT*, A.
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