Fatty acid (FA) balance is strictly related to human health. The composition of fatty acids in lipid membranes seems to be influenced by diet. Shark liver oil (SLO) supplementation has been widely used recently in the prevention and treatment of human diseases. We analyzed the impact of short-term SLO supplementation on certain biochemical parameters and erythrocyte FA composition in a group of young healthy women. Our results showed that 6 weeks of SLO supplementation led to a significant decrease in C-reactive protein levels in sera and intracellular cholesterol levels in peripheral blood mononuclear cells. SLO supplementation caused a significant increase in the content of the polyunsaturated omega-3 FAs: docosahexaenoic acid, docosapentaenoic acid and α-linolenic acid. In the group of omega-6 FAs, we observed a significant elevation of arachidonic and dihomo-gamma-linoleic acid content. Due to these alterations, the omega-3 index increased significantly from 3.6% (before) to 4.2% (after supplementation). We also observed the impact of SLO supplementation on the membrane fluidity index. The ratio between saturated and unsaturated FAs decreased significantly from 13.1 to 9.9. In conclusion, our results show that even short-term SLO supplementation can improve human erythrocyte fatty acid composition and other parameters that may have health-promoting consequences.
Patients treated with biologic drugs for various-not only dermatological-diseases are growing in number. Biologic drugs applied as a long-term therapy of psoriasis are safe, enable disease remission, and most importantly, help improve the patient's quality of life. It is also crucial to note, that biologic agents decrease patient mortality rate. Much research has shown the unquestionable efficiency of biologic therapies despite their also well-documented rare adverse effects. Due to the growing range of application of these agents, it is critical to keep an observant eye during the monitoring of the patient in case of new disease activity. This study aims to present the case of a female patient treated with etanercept for severe psoriasis arthritis (PsA) who subsequently developed acute sarcoidosis and to examine the risk of serious adverse events.
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