STRESZCZENIEWPŁYW STOSOWANIA OKOŁOPORODOWEJ PROFILAKTYCZNEJ ANTYBIOTYKOTERAPII NA WYSTĘPOWANIE ZAKAŻEŃ WCZESNO-OBJAWOWYCH U NOWORODKÓW Cel pracy. Celem pracy była ocena skuteczności profilaktycznej okołoporodowej antybiotykoterapii na występowanie wczesnoobjawowych zakażeń. Materiały i metodyka. Materiał do badań stanowiły uzyskane z historii chorób dane 1328 żywo urodzonych, pojedynczych noworodków i ich matek. Badane parametry ciągłe opisano podając liczebność, średnią arytmetyczną, odchylenie standardowe, medianę oraz najmniejszą i największą wartość. Do analizy frakcji użyto testu Chi kwadrat; także z poprawką Yatesa (dla małych liczebności komórek). Poziom istotności statystycznej przyjęto dla p<0,05. Wyniki. U 6,62% noworodków wystąpiło zakażenie wczesno-objawowe. Infekcję GBS stwierdzono u 14 z nich, lecz tylko u 5 z nich wyizolowano wyłącznie GBS. E. coli stwierdzono u 33 noworodków, a "inne bakterie", w tym Enterococcus faecalis, Enterobacteriaceae, Staphylococcus epidermidis, Staphylococcus aureus wyizolowano od 42 noworodków. U 24 noworodków występowały objawy kliniczne zakażenia oraz dodatnie wskaźniki stanu zapalnego w badaniach laboratoryjnych, przy ujemnych wynikach posiewów bakteriologicznych. Wnioski. W związku z wprowadzeniem obowiązku wykonywania badań w kierunku GBS ilość stosowanej antybiotykoterapii wzrasta. Skuteczność śródporodowej antybiotykoterapii oraz jest powszechność wydają się być zadowalające. Kolor wód płodowych może mieć wpływ na występowanie infekcji wewnątrzmacicznej, w tym wczesnoobjawowego zakażenia GBS. Słowa kluczowe: nosicielstwo GBS, zakażenie, poród, antybiotykoterapia ABSTRACT THE EFFECT OF PERINATAL ANTIBIOTIC PROPHYLAXIS ON AN EARLY ONSET OF SYMPTOMATIC INFECTIONS IN NEWBORNSAim. The aim of the study was to evaluate the effectiveness of preventive perinatal antibiotic therapy on the occurrence of an earlysymptomatic infections in newborns. Material and Methods. The studied material consisted of data obtained from medical records of 1,328 born alive infants and their mothers. Advanced parameters were described with appropriate numbers, arithmetic means, standard deviation, median as well as minimum and maximum values. The level of statistical significance was p<0.05. Results.When it comes to 6.62% of newborns, they demonstrated the presence of early signs of infection. The Group B Streptococcus (GBS) infection was found in 14 cases, but only in 5 of them pure GBS strains were isolated. E. coli bacteria was reported in 33 neonates, while the other bacteria naming: Enterococcus faecalis, Enterobacteriaceae, Staphylococcus epidermidis, Staphylococcus aureus were isolated from 42 newborns. Among 24 newborns showing clinical signs of infection and positive indicators of inflammation in laboratory tests, simultaneously negative results of bacteriological cultures were reported. Conclusions. In connection with the introduction of an obligation to perform tests for GBS, amount of used antibiotics is increasing. However, the effectiveness of intrapartum antibiotic therapy and ...
Objective. The aim of the study was to assess the effectiveness of an antibiotic prophylaxis in order to reduce perinatal percentage of early-symptomatic infections in newborn infants. Materials and method. Material for the study was obtained from the medical records of 1,328 live born individual infants and their mothers. Tested continuous parameters were described with the appropriate numbers, arithmetic mean, standard deviation, median and minimum and maximum values. For analysis of fractions the Chi square was used; also with Yates correction (for a small number of cells). Level of statistical significance -p<0.05. Results. The duration of pregnancy in mothers who gave birth to newborns without evidence of GBS infection was significantly longer than the duration of pregnancy in mothers whose infants were infected with Group B streptococcus (GBS) (39.2 vs 38.3 weeks gestation). In 13 infants infected during delivery, antibiotic prophylaxis was not used (92.86%), while it was used in only one case (7.14%). Perinatal prophylaxis was used in 26.81% of the surveyed mothers. Conclusions. The use of maternal antibiotic prophylaxis can have an impact on lowering the percentage of GBS infections in newborn infants. A trend of reducing the proportion of earlysymptomatic infections has been observedin recent years. The type of delivery does not seem to have a decisive influence on the incidence of GBS-based infection. The colour of the amniotic fluid does not determine the presence of the GBS infection.
Aim of the study: To analyse neonates with bacteriologically negative congenital infections with regard to the type of labour and intrapartum antibiotic prophylaxis (IAP). Material and methods: The research material included the medical history data of 1328 born-alive neonates from single pregnancies, and the data of their mothers. A c 2 test (also with Yates correction) was employed to perform fraction analysis. The level of significance was set at p < 0.05. Results: The neonates with congenital infections were hospitalised for considerably longer than the uninfected ones irrespective of whether they were born vaginally (p < 0.001) or via C-section (p < 0.0007). The uninfected neonates scored significantly higher on the Apgar scale (p < 0.0001). 1.23% of the mothers who did not receive IAP and 3.37% of those who received IAP gave birth to ill neonates. The total percentage of infants with clinically confirmed infections was 1.81% (p = 0.0096). Clinically confirmed congenital infections were found in 1.13% of the neonates from vaginal labours and 4.55% of those born via C-section (p = 0.0001). Conclusions: Early symptomatic infections in neonates can develop without positive bacteriological culture results. IAP can modify the occurrence and/or the course of clinically confirmed congenital infections. Empirical antibiotic treatment of infections administered during the first 24 hours does not seem to be the best solution; however, currently it is necessary. The colour of amniotic fluid and the type of labour, especially when accompanied by other risk factors, may suggest an infection.
Introduction: A significant decline in the proportion of the perinatal mortality of foetuses and newborns has been observed in recent years. The use of perinatal antibiotic therapy in order to reduce the risk of infection, including strains of group B Streptococcus (GBS) -Streptococcus agalactiae contracted during birth, is one of the reasons for this outcome. Materials and methods: Material for the study was obtained from medical record data covering 1,328 live births of individual infants and their mothers. The analysed continuous parameters are described with appropriate numbers, arithmetic mean, standard deviation, and median, minimum and maximum values. Discrete parameters (qualitative) are expressed as percentages (fractions). The arithmetic means between groups were compared using Student's t-test. For analysis of fractions the χ 2 test was used with the Yates correction (for a small number of cells). The level of statistical significance was accepted at p < 0.05. Results:The mean age of women giving birth was estimated at 27.5 ±5.1 years. The mean duration of pregnancy was 39.2 ±1.6 weeks. The mean time from the rupture of the amniotic sac to completion of birth was 352.2 ±925.2 minutes. The total time of the childbirth of an infected newborn was significantly longer then the birth of a healthy newborn (453.3 vs 383.8; p < 0.0001). The Apgar score was significantly higher in healthy newborns then in infected ones (9.3 vs 8.6; p < 0.0001). The percentage of treated pregnant women scored 26.81%, while those with a positive culture was 78.43% (p < 0.0001). Conclusions:The use of perinatal antibiotic prophylaxis reduces the incidence of early GBS infections in newborns. The use of perinatal antibiotic therapy in the absence of GBS culture is not a common procedure. However, by comparing years 2007-2011, it is practiced more and more. The occurrence of the GBS carrier state is common. Keywords: carriers of GBS; infection; childbirth; antibiotic.ABSTRAKT Wstęp: W ciągu ostatnich lat obserwowane jest wyraźne obniżanie się odsetka umieralności okołoporodowej płodów i noworodków. Jedną z przyczyn takiego stanu jest zastosowanie okołoporodowej antybiotykoterapii celem zmniejszania ryzyka zakażenia okołoporodowego m.in. szczepami paciorkowca grupy B (GBS) -Streptococcus agalactiae. Materiały i metody: Materiał do badań stanowiły uzyskane z historii chorób dane 1328 żywo urodzonych, pojedynczych noworodków i ich matek. Badane parametry ciągłe opisano, podając odpowiednią liczebność, średnią arytmetyczną, odchylenie standardowe, medianę oraz najmniejszą i największą wartość. Parametry dyskretne (jakościowe) przedstawiono jako odpowiednie procenty (frakcje). Średnie arytmetyczne mię-dzy grupami porównano testem t-Studenta. Do analizy frakcji użyto testu χ 2 , także z poprawką Yatesa (dla małych liczebności komórek). Poziom istotności statystycznej przyjęto dla p < 0,05. Wyniki: Średni wiek rodzących wyniósł 27,5 ±5,1 lat. Średni czas trwania ciąży wyniósł 39,2 ±1,6 tygodnia ciąży. Średni czas od pęknięcia pęch...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.