Fragmental topology-activity landscapes (FRAGTAL), a new concept for encoding molecular descriptors for fragonomics into the framework of the molecular database records is presented in this paper. Thus, a structural repository containing biological activity data was searched in a substructure mode by a series of molecular fragments constructed in an incremental or decremental manner. The resulted series of database hits annotated with their activities construct FRAGTAL descriptors encoding a frequency of the certain fragments among active compounds and/or their activities. Actually, this method might be interpreted as a simplified adaptation of the frequent subgraph mining (FSM) method. The FRAGTAL method reconstructs the way in which medicinal chemists are used to designing a prospective drug structure intuitively. A representative example of the practical application of FRAGTAL within the ChemDB Anti-HIV/OI/TB database for disclosing new fragments for HIV-1 integrase inhibition is discussed. In particular, FRAGTAL method identifies ethyl malonate amide (EMA) as the diketo acid (DKA) related arrangement. Since new molecular constructs based on the EMA fragment are still a matter of future investigations we referred to this as anthe DKA offspring.
The amendment of 5 July 2018 introduced some changes to the Trade Unions Act of 1991 in the scope of the rules for the acquisition and loss of legal status of a company trade union by trade unions in the workplace. The legislator extended the catalogue of events resulting in the loss of the status of a company trade union organization and established a juridical procedure for verifying the number of trade union members indicated in the information presented to the employer. These amendments were aimed at eliminating the state of uncertainty resulting fromthe existing regulations. However at the sametime, the legislator did not regulate the legal consequences of losing the status of a company trade union organization in relation to the sphere ofcompany sources of labor law. The author notices the legal gap in this field and related interpretation problems, indicating the need for regulating this issue by the legislator
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