(1) Background: Cancer treatment, including chemotherapy, endocrine therapy, targeted therapy and radiotherapy, has been identified as an important independent risk factor for venous thromboembolism in cancer patients. The aim of the study was to evaluate the effect of adjuvant therapy on the coagulation and fibrinolysis components in invasive breast cancer. (2) Methods: Tissue factor pathway inhibitor (TFPI), tissue factor (TF), tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) antigen (concentration) and TFPI and TF activities were examined in the blood samples of 60 breast cancer patients treated by adjuvant chemotherapy, endocrine therapy, radiotherapy and immunotherapy. Blood samples were taken 24 h before primary surgery and 8 months after tumour removal surgery. (3) Results: Adjuvant therapy administrated to breast cancer patients significantly increased the concentration of plasma TF, the PAI-1 antigen and also the activity of TFPI and TF, but significantly decreased the level of the t-PA antigen. Combined chemotherapy and endocrine therapy, but not monotherapy, has an important effect on haemostatic biomarker levels. (4) Conclusions: Breast cancer patients receiving adjuvant therapy have an elevated risk of developing a hypercoagulability and hypofibrinolysis state leading to venous thromboembolism.
Prezentowane wspomnienia o zmarłym 8 lutego 2022 r. Krzysztofie Kuszewskim stanowią wyraz uznania środowiska zdrowia publicznego dla Jego życiowej działalności, która wywarła duży wpływ na rozwój tej dziedziny w najnowszej historii nauk o zdrowiu w Polsce.
Total hip arthroplasty with metal-on-metal bearing is associated with specific complications: local delayed hypersensitivity reaction (ALVAL) to metal particles, osteolysis and the development of pseudotumors. This process results from the low resistance of the metal bearing to abrasion and corrosion, which causes the release of metal ions into the surrounding tissues. This paper presents the case of a 54-year-old man who required revision surgery due to aseptic loosening of the endoprosthesis with a ceramic (TiN)-on-metal bearing. The removed implants were subjected to material analysis. Mean chemical analysis revealed that the main component of the residue samples was titanium, which constituted 65% of the sample weight, followed by calcium (16%), phosphorus (11%) and aluminum (3.8%). The fissures on the insert were a result of trauma caused by the head, with both elements matching in terms of visible damage. More than 50% of the surface of the head had been damaged due to abrasive wear. The transitional area between the normal and completely delaminated TiN coating shows uneven abrasion, a gradual decrease in coating thickness. In conclusion, the use of endoprosthesis heads with TiN ceramic coating involves very low polyethylene wear. The low resistance of TiN ceramic coating to trauma and the fragility of this coating prevent the use of TiN-coated heads in combination with any non-polyethylene hip endoprosthesis inserts.
Dissolution of the white border of the rectus abdominal muscle is a disruption of the functioning of the rectus muscle, which results in loosening of the white border. As a result, a characteristic muscle stretch is visible. This defect affects a significant number of pregnant women and is not just an aesthetic problem. There are many factors that contribute to the above-mentioned ailments. To get the best treatment results, it is important to diagnose the problem early. For this purpose, special tests are used. The ease with which they are made enables the patient to control the separation of the frontier by the patient.The implementation of therapy should take place already in the first days after delivery. It is important to start therapy with posture corrective exercises, breathing exercises and learning how to properly perform everyday activities. Then we implement exercises that involve the abdominal muscles. The exercise program can be supplemented with dynamic slicing. A holistic approach to the problem and combining different forms of therapy allows
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