Background: Atrial fibrillation (AF) is associated with high risk of stroke preventable by timely initiation of anticoagulation. Currently available screening tools based on ECG are not optimal due to inconvenience and high costs. Aim of this study was to study the diagnostic value of apelin for AF in patients with high risk of stroke.Methods: We designed a multicenter, matched-cohort study. The population consisted of three study groups: a healthy control group (34 patients) and two matched groups of 60 patients with high risk of stroke (AF and non-AF group). Apelin levels were examined from peripheral blood.Results: Apelin was significantly lower in AF group compared to non-AF group (0.694 ± 0.148 vs. 0.975 ± 0.458 ng/ml, p = 0.001) and control group (0.982 ± 0.060 ng/ml, p < 0.001), respectively. Receiver operating characteristic (ROC) analysis of apelin as a predictor of AF scored area under the curve (AUC) of 0.658. Apelin's concentration of 0.969 [ng/ml] had sensitivity = 0.966 and specificity = 0.467. Logistic regression based on manual feature selection showed that only apelin and NT-proBNP were independent predictors of AF. Logistic regression based on selection from bivariate analysis showed that only apelin was an independent predictor of AF. A logistic regression model using repeated stratified K-Fold cross-validation strategy scored an AUC of 0.725 ± 0.131.Conclusions: Our results suggest that apelin might be used to rule out AF in patients with high risk of stroke.
BorseKová K, Cole D., PetríkoVá k., VAňoVá A., 2015. Nostalgic sentiment and cultural and creative industries in regional development: a Slovak case study. Quaestiones Geographicae 34(2), Bogucki Wydawnictwo Naukowe, Poznań, pp. 53-63, 3 figs, 3 tables. DOI 10.1515/quageo-2015-0015, ISSN 0137-477X.aBstraCt: In Slovakia, there are three unique, historical mining towns, Banská Bystrica, Banská Štiavnica and Kremnica, that have been successfully turned into creative cultural centres. The historical and cultural values of those towns have stood the test of time and become a magnet for a new and creative class of people looking to escape the brutality of high modernity (modern urban centres) and find a source of inspiration based on historical nostalgic sentimentalism -the basis for a new creative and cultural industry for rural areas. The main objective of this paper is to analyse the cultural and creative industries of these three unique historical mining centres with an eye to replicating their knowledge in other communities in economic stress. The paper will first explore concepts relating to cultural and creative industries with an eye towards nostalgic sentimentalism that is an important antithesis to high modernity, and even post-modernity. The second part will analyse the cultural and creative industries of the three centres based on primary data collected from several research projects in this area. The final part will provide some recommendations for the facilitation of creative and cultural enterprises in regional redevelopment. It also contains policy recommendations for the self-government of the region for a more effective and rational exploitation of the existing potential hiding in plain view.
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