Five new [daphneodorins D–H
(1, 5, and 10–12)] and seven known daphnane
diterpenoids (2–4 and 6–9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive
physicochemical and spectroscopic analysis. The isolated compounds
were evaluated for their anti-HIV activity against HIV-1 infection
of MT4 cells. Nine daphnane diterpenoid orthoesters (1–9) showed potent anti-HIV activity with EC50 values of 1.5–7.7 nM.
A facile
and regioselective synthesis of quinoxalines, an important
motif in medicinal chemistry and materials sciences, was developed.
Despite their prospective utility, the regioselective preparation
of trisubstituted quinoxalines has not been previously established.
In the reported system, hypervalent iodine reagents catalyzed the
annulation between α-iminoethanones and o-phenylenediamines in a chemo/regioselective
manner to afford trisubstituted quinoxalines. Excellent regioselectivities
(6:1 to 1:0) were achieved using [bis(trifluoroacetoxy)iodo]benzene
and [bis(trifluoroacetoxy)iodo]pentafluorobenzene as annulation
catalysts.
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