In the present studies silicon based low density ablative material has been studied for its ablative performance to protect flight hardware from temperature raised due to aerodynamic forces for longer duration. Ablative properties are estimated by oxyacetylene flame test at 100-120 W/m 2 heat flux. The time duration for the flame test is taken 200 sec. The material shows low mass and linear ablation rate with high ablative effectiveness. The degradation kinetics of silicon ablator is studied by Thermo Gravimetric Analysis (TGA) method. Non-isothermal TGA is performed in the temperature range of 30 °C to 900 °C at various heating rates viz. 5, 10, 15 and 20 o C/ min. Knowledge of the kinetic parameters of thermal decomposition is used to predict degradation kinetics of the material at high heating rates which the ablator faces during aerospace applications.During ablation the silicone ablative material consist of a virgin zone, reaction zone and char zone.These are explained by kinetic parameters which are determined with help of free software called Kinetic Calculation.
Background A simple and reliable HPLC method for the determination of impurities in Eltrombopag olamine (ELO) film-coated tablets were not available. At the same time, there was no official monograph reported. The proposed research targeted at development of a stability-indicating method for determining impurities in ELO film coated tablets and drug substances. Objective To develop and validate a simple and effective HPLC method for the determination of impurities in ELO film-coated tablets and drug substances. Method All the impurities were separated using the RP-HPLC system equipped with Zorbax SB-Phenyl 150 mm x 4.6 mm, 3.5 µm, column with UV detection at 230 nm with the flow rate of 1.2 mL/min. The column temperature was maintained at 45 °C. Results The proposed method was validated as per current regulatory guidelines. The coefficient of correlation was found to be > 0.999 for all impurities. The limit of detection and quantification for ELO and all specified impurities was determined. The precision and accuracy were obtained for ELO and their related impurities. Intra and inter-day % RSD values were between 1.22% to 2.04%, and recovery of impurity varied between 93.80 to 103.69%. The stability of standard and sample solutions was established for 24 hrs. Conclusion As per recent guidelines, a stability-indicating method has been developed to determine the impurities in ELO film-coated tablets and drug substances. QbD-based robustness was performed and proved that the method was robust. Highlights The proposed article is the first-ever RP HPLC method for determining impurities in ELO film-coated tablets and drug substances. QbD concept was utilized to verify the method performance.
Background Peramivir, a neuraminidase inhibitor that serves as a transition-state analogue for influenza, inhibiting the formation of new viruses in infected cells and also been approved for intravenous administration. Objective To validate the HPLC method to identify the degraded products of the antiviral drug Peramivir. Methods Herein, we report the identification of degraded compounds formed after the degradation of the Peramvir an antiviral drug done by the acid, alkali, peroxide, thermal and photolytic degradation. At the level of toxicology, a technique was devised for the isolation and measurement of the compound known as peramivir. Results A sensitive and reliable liquid chromatography-tandem mass spectrometry technique to the quantitative measurement of Peramivir and also its impurities was developed and verified in order to comply with the recommendations made by ICH. The proposed protocol was in the 50–750 µg/mL range. RSD values less than 2.0% indicate good recovery in the range of 98.36%-102.57%. Within the studied range, the calibration curves demonstrated good linearity, in addition, the coefficient of fitting correlation was more than 0.999 for every impurity. Contaminant quantitative analysis revealed the high efficiency at a low level. Conclusion Given its ability to separate degradation products, quantitative analysis is used to detect and quantify known and unknown impurities and degradants in the Peramivir drug substance during routine analysis and stability studies. No significant degradation was found in peroxide and photolytic degradation studies. Highlights An HPLC method was developed and put to the test in order to analyse the behavior of the impurities of peramivir as they degraded when subjected to the stress conditions suggested by the ICH. The compound was discovered to be stable under peroxide and photo conditions but degradable towards the acid, base and thermal. The method developed was extremely precise, linear, accurate, robust, and rugged. As a result, this technology has the potential to be used in the medication production process for regular impurity analysis as well as for the stability analysis of peramivir.
In the present studies silicon based low density ablative material has been studied for its ablative performance to protect flight hardware from temperature raised due to aerodynamic forces for longer duration. Ablative properties are estimated by oxyacetylene flame test at 100-120 W/m2 heat flux. The time duration for the flame test is taken 200 sec. The material shows low mass and linear ablation rate with high ablative effectiveness. The degradation kinetics of silicon ablator is studied by Thermo Gravimetric Analysis (TGA) method. Non-isothermal TGA is performed in the temperature range of 30 °C to 900 °C at various heating rates viz. 5, 10, 15 and 20 oC/ min. Knowledge of the kinetic parameters of thermal decomposition is used to predict degradation kinetics of the material at high heating rates which the ablator faces during aerospace applications. During ablation the silicone ablative material consist of a virgin zone, reaction zone and char zone. These are explained by kinetic parameters which are determined with help of free software called Kinetic Calculation.
Adsorption technology has been successfully employed for controlling water pollution. Surface chemistry, surface modification, nature of adsorbent and adsorbate plays a vital role in the Adsorption phenomenon which has been studied by using KMnO4 modified adsorbents. From the present studies the experiments have been carried out by using KMnO4 modified plant materials as bioadsorbents and the order of efficiency of removal of SO2 is found to be Citrus limetta >Abelmoschus esculentus > Hevea brasilensis > Hibiscus sabdariffa > Bacopa monnieri > Aloe barbadensismiller > Psidium guajava > Nelumbo nucifera > Fenugreek > Amaranthus. Keywords: Adsorption; Water pollution; Adsorbent; Adsorbate; Removal of SO2; Surface modification; Plant materials; Bioadsorbents;
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