During this COVID-19 pandemic, except steroid, none of the therapeutic measures have showed any evidence of efficacy. Traditionally jala-neti using lukewarm salted water remains a yogic way of maintaining upper airway hygiene. Saline irrigation decreases the concentration of inflammatory mediators (e.g. histamine, leukotriene etc.) in nasal secretions, reduces the severity and frequency of sinusitis, reduce need of antibiotic therapy and restores competency of nasal mucosa. Jala-neti is an integral part of six cleansing techniques of yogic kriyas practised in India since thousands of years. Jala-neti can clean the upper airways, prevents colonization of infectious agents, removes foreign bodies, prevents stasis of mucous and subsequently enhances the drainage of paranasal sinuses and maintain health. Regular practice of Jala neti improves nasal symptoms and overall health status of patients with sinusitis. Jala-neti sample can even be used for COVID-19 diagnosis. Povidone iodine (PVP-I) has been utilized as a time tested antimicrobial agent with broad spectrum coverage against wide range of bacteria and viruses. Anti-SARS-CoV-2 action of PVP-I was seen at a concentration as low as 0.45% . PVP-I is generally well tolerated upto 5%, however nasal ciliotoxicity is reported at this concentration, however, this toxicity is not reported with lower concentrations(1.25% and 0.5%). So, theoretically, by using neti-kriya with povidone iodine (0.5–1%) as irrigation solution can combine and enhance the protection against COVID-19 and this can be an important armor in the fight against COVID-19. However, this hypothesis needs to be validated in real life clinical trial scenario before implementing.

The current study was conducted to determine the role of C-reactive protein (CRP) and lactate dehydrogenase (LDH) as prognostic-marker and outcomes of different pharmacotherapeutic agents among patients with cerebrovascular accident (CVA). A hospital-based observational study was conducted and patients with CVA admitted were included. Serum-CRP on admission correlated positively with modified Rankin score (mRS) ( r = 0.9, P < 0.001) in ischemic stroke, whereas no correlation between serum LDH with mRS ( r = 0.1, P = 0.5) was observed. Neither CRP nor LDH was helpful in predicting the outcome in hemorrhagic stroke. The use of Vitamin B12 was associated with favorable outcome in ischemic CVA cases and use of folic acid was associated with favorable outcome among hemorrhagic-CVA patients.

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Background- Spontaneous breathing trial is one of the most promising procedure to successfully extubate a patient from mechanical ventilation. Commonly used modalities for weaning are PSV and T-tube. The aim of this study is to compare the re-intubation rates between these two strategies. This is an obse Methodology- rvational study done in the Central ICU under Department of Anaesthesiology, Assam medical college and hospital during the time period of June 2021 to May 2022. The study participants were recruited based on inclusion and exclusion 1 criteria. The sample size was calculated to be 66 [33 in each group] taking the reference of C.Subira . Demographic details and ASA status was obtained and once patient's clinical condition was improved they were put into spontaneous breathing trial either with T-tube or PSV. Hemodynamic changes were noted and if patients were tolerating the trial, extubation was done and they were observed. Re-intubation rates following 48 hours of extubation were compared between both the groups. Statistical analysis was done with SPSS software. Categorical variables were expressed in terms of numbers and percentages and p value <0.05 was considered stastistically significant. In our study demographics showed no si Results- gnificant variation. Re-intubation rates were more in Ttube group (24.24%) compared to PSV (12.12%) but was statistically insignificant. Our study s Conclusion- howed comparable rates of re-intubation between both the groups of T-tube and PSV

Background: Hypotension following spinal anaesthesia during elective caesarean commonly seen either due to decreased in vascular tone or decreased cardiac output because of blood pooling. Peripheral perfusion index (PI) being a non-invasive measure of real time change in peripheral blood flow can be a dynamic measure in prediction of hypotension. This is a prospective study done in Assam Medical college and hospital recruiting 100 Methodology: parturient based on inclusion and exclusion criteria. They were divided into two groups with 50 parturient in each group with baseline PI>3.5 and <3.5 respectively. The statistical analysis was done using SPSS. Statistical significance was fixed at 5% level (p value <0.05). Majority of parturient were less than 25years of age, less than 160cms Results: in height and weight less than 65kgs in both groups. No statistical significance observed between the study groups in terms of duration of surgery. The incidences of Hypotension in Group I (PI > 3.5) was 54% compared to Group II (PI ≤ 3.5) which was 13% and was highly statistically significant (p=0.001). Parturient with a baseline PI >3.5 were Conclusion: at higher risk of developing hypotension compared to those with a baseline PI ≤ 3.5 following spinal anaesthesia. Thus, preoperative baseline PI can be used as a predictive tool for hypotension.