Microwave assisted domino intramolecular Heck and Sonogashira coupling for the efficient synthesis of alkyne substituted dihydrobenzofurans is presented.
An effective domino one-pot [Pd]-catalysis for the construction of novel tetracyclic compounds was described. This process involved in the construction of three C-C bonds from simple and readily available 1-bromo-2-isopropenylbenzenes and internal alkynes. A variety of fused tetracyclic dihydroindeno-indenes were accomplished.
An environmentally benign microwave‐assisted domino [Pd]‐catalyzed reaction, for the efficient and diverse synthesis of 3,3′‐disubstituted indolines, oxindoles, and dihydrobenzofurans, is presented. Significantly, water served as the sole green solvent and the strategy displayed an excellent functional‐group tolerance. Remarkably, the process was also amenable to unmasked functional groups and furnished the products, in very good to almost quantitative yields.
A domino [Pd]‐catalyzed intramolecular Heck cyclization followed by intermolecular phosphorylation, for the construction of phosphorus containing heterocyclic compounds, is presented. Notably, the process is accelerated by microwave heating conditions and enabled the construction of C–C and C–P bonds in short reaction times.
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