An abundance of evidence exists in support of primary and secondary prevention for tackling the scourge of cardiovascular disease. Despite our wealth of knowledge, certain deficiencies still remain. One such example is the association between sleep disordered breathing (SDB) and cardiovascular disease. A clear body of evidence exists to link these two disease entities (independent of other factors such as obesity and smoking), yet our awareness of this association and its clinical implication does not match that of other established cardiovascular risk factors. Here, we outline the available evidence linking SDB and cardiovascular disease as well as discussing the potential consequences and management in the cardiovascular disease population.
Introduction Accurate assessment of patients presenting with suspected cardiac pain is of paramount importance as it determines management strategy. Angina itself is a clinical diagnosis and assessing its prognostic significance may require further investigation. NICE provide a framework to aid accurate diagnosis and evaluation (Clinical Guideline 95). Clinicians are encouraged to assess the prognostic significance of underlying coronary disease based on pre-test probability (PTP). Stress Echocardiography (SE) is a non-invasive assessment tool recommended in those patients with a PTP of 30–60%. The primary purpose of this audit was to establish how closely clinicians followed the NICE Clinical Guideline 95 when referring for SE. Furthermore, we wished to evaluate the utility of SE in groups with other PTPs. Methodology A retrospective analysis of patients referred for SE at Mid Yorkshire Hospitals NHS Trust between March and May 2013 was performed. Consecutive referrals from hospital clinicians within the trust were included, both for exercise and dobutamine testing. Exclusion criteria included referrals for indications other than chest pain and those with established coronary artery disease. Results 193 patients were evaluated in total. The patients were of a typical demographic profile for suspected coronary disease, with the most common age group being 41–60 (48% of total). 55% were male. 31% were on no anti-anginals prior to referral. 22% (42/193) had typical angina whilst 57% (110/193) described non-anginal pain as judged by the cardiologist supervising the SE. Only 13% (25/193) had a PTP of 30–60%, of which only 16% (4/25) had a positive SE. The most common PTP category was 61–90% (81/193). Of all SE performed, 18% (34/193) were positive. Of these, 56% (19/34) were referred for angiogram and 53% of this cohort (10/19) had angiographically significant lesions requiring intervention. Most interestingly, only 7 of the 110 patients describing non-anginal pain had a positive SE. Of these, 3 were sent for invasive angiography and none required revascularisation. Conclusions NICE advocates the use of SE for a specific group of patients based on PTP, but a much broader selection across all risk groups are currently being referred within the trust. SE is being performed on patients with non-anginal pain and this should be evaluated in light of such data showing that of 107 patients, not a single one went forward for revascularisation. This accentuates the paramount importance of accurate history-taking and demonstrates clearly that non-anginal presentations confidently exclude flow-limiting lesions and therefore do not require further testing. We advocate similar studies within other trusts to establish whether findings are replicated. Continuing unconsciously outside of NICE guidance is unsustainable on clinical grounds and additionally, it prohibits adequate workforce planning. Abstract 138 Figure
Accurate diagnosis of stable angina is of paramount importance, and where possible, this should be based on clinical history. In cases of uncertainty, the National Institute for Health and Care Excellence (NICE) provides a framework for assisting diagnosis based on pre-test likelihood (PTL) of coronary artery disease. Functional testing such as stress echocardiography (SE) is recommended as a first-line investigation in patients with PTL of 30–60%. This study evaluated hospital clinicians' adherence to this recommendation. A prospective analysis of patients referred for SE at a district general hospital between March and May 2013 was performed. Data were extracted from an electronic database of SE reports and medical notes. A total of 193 patients were assessed. The most common PTL was 61–90%, accounting for 40% of the cohort. Of them, 14% had a PTL of 30–60%. Of these, 15% had positive SE; 57% described non-anginal pain, as defined by NICE, of whom only nine cases had SE positivity. None of these patients required revascularisation. Findings suggest that SE is being used in a much broader selection group than advocated by NICE. This may often be for its exclusion value rather than to stratify risk. Although utility may be justified in high-risk patients to avoid proceeding directly to invasive angiography, SE appears to add little in those with non-anginal pain and with low PTL. Greater focus should be directed towards characterisation of symptoms, which may negate the need for subsequent investigation.
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