This tutorial review highlights the use of palladium-catalyzed cascade cyclizations in natural product synthesis, focusing on cascades that construct multiple rings and form both C–C and C–X (X = O, N) bonds in a single synthetic operation.
Held June 24–25, 2021, the third annual Empowering Women in Organic Chemistry (EWOC) conference gathered organic chemists at all stages of the career pipeline for rich professional development opportunities and a showcase of recent scientific achievements. This Meeting Review outlines the program.
Radical and transition metal-catalyzed cascade cyclization strategies were investigated with respect to the synthesis of the tetracyclic core of the augustamine-type Amaryllidaceae alkaloids. These studies resulted in the synthesis of noraugustamine and the development of an oxidative Heck/aza-Wacker cascade forming two rings, a C−N bond, and an all-carbon quaternary center in a single step.
This article describes the procedure for iridium‐catalyzed reductive coupling of grignard reagents and tertiary amides. It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. The article also describes the hazards associated with N,Ndimethylbenzamide, carbonylchlorobis(triphenylphosphine)iridium (I), dichloromethane, 1,1,3,3‐tetramethyldisiloxane, ethylmagnesium bromide (3.0 M in diethyl ether), diethyl ether, hydrochloric acid in dioxane (4.0 M), ethyl acetate, and methanol. The mild, yet highly active and chemoselective catalytic system formed from Vaska's complex and 1,1,3,3‐tetramethyldisiloxane allows reductive coupling of Grignard reagents to amides in an efficient fashion. This reaction offers a new strategy for the efficient and scalable synthesis of tertiary a‐branched amines including application in late‐stage functionalization.
Held June 24–25, 2021, the third annual Empowering Women in Organic Chemistry (EWOC) conference gathered organic chemists at all stages of the career pipeline for rich professional development opportunities and a showcase of recent scientific achievements. This Meeting Review outlines the program.
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