Objective The purpose of this study was to compare the frequency of the occurrence of high-risk human papillomavirus (HPV) and abnormal anal cytology in immunocompetent women with and without HPV-induced genital lesions. Methods This analytical cross-sectional, observational study was conducted between July 2017 and December 2018 in a specialized outpatient clinic of a tertiary hospital in Fortaleza, CE. Fifty-seven immunocompetent women with and without genital intraepithelial lesions were assessed; they were divided into two groups: group 1 was comprised of women with HPV-associated genital lesions (n = 26), and group 2 was comprised of those without HPV-associated genital lesions (n = 31). Samples for liquid-based cytology and high-risk DNA-HPV polymerase chain reaction real-time tests were collected from the cervix and anus. All cases were evaluated using high-resolution anoscopy; biopsies were performed when required. The Fisher exact and chi-squared tests were applied for consolidated data in the contingency table, and the Student t-test and Mann-Whitney U-test for independent variables. Results Anal high-risk HPV infections were more frequent in group 1 (odds ratio [OR], 4.95; 95% confidence interval [CI], 1.34–18.3; p = 0.012), along with concomitant high-risk HPV infections in the uterine cervix and the anus (OR 18.8; 95% CI, 2.20–160; p < 0.001). The incidence of high-risk cervical HPV infection was associated with high-risk anal HPV infection (OR, 4.95; 95% CI, 1.34–18.3; p = 0.012). There was no statistical difference concerning abnormal anal cytology or anoscopy between the groups, and no anal intraepithelial lesion was found in either group. Conclusion Immunocompetent women with HPV-associated genital lesions and high-risk cervical HPV were more likely to have high-risk anal HPV.
As lesões malignas primárias da vagina são incomuns e os sarcomas vaginais são ainda mais raros. leiomissosarcomas são tumores que se originam do musculo liso. Descrevemos um caso raro de leiomiossarcoma mixoide de vagina com proposta inicial de tratamento cirúrgico. Uma mulher de 31 anos com vida sexual ativa apresentou massa vaginal, cujo exame histopatológico revelou leiomiossarcoma mixoide vagina sendo necessário estudo imunohistoquímico complementar que confirmou o diagnóstico. A paciente foi submetida a cirurgia para exérese da lesão, com bom resultado. A paciente permanece em acompanhamento no ambulatório de cirurgia oncológica, e apresenta-se sem recidiva de doença. A experiência com leiomiossarcomas vaginais é limitada. Os métodos ótimos de tratamento ainda não foram estabelecidos devido à raridade do tumor.
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