There is a relationship between damp buildings and health complaints. Damp conditions in building constructions also favour the growth of micro-organisms. Growth of micro-organisms results in the production of volatile organic compounds, which has been shown to have an impact on Indoor-air monitored via a microbial volatile organic compound (MVOC) analysis. In order to widen the applicability of MVOC analysis, it is necessary to increase this analysis by including more volatiles. By active sampling on Anasorb 747 and selected ion monitoring on a mass spectrometer equipped with a quadropole detector, it is possible to determine these volatiles with sufficient accuracy in indoor air of non-industrial buildings.
3, S h a r o n 2 S t o n e -E l a n d e r ' , B e n g t L5ngstrOm4 a n d T o r g n y G r e i t z K a r o l i n s k a P h a r m a c y , B o x 6 0 0 2 4 , S -1 0 4 01 S t o c k h o l m , S w e d e n 2 D e p a r t m e n t o f N e u r o r a d i o l o g y , K a r o l i n s k a H o s p i t a l , S -1 0 4 01 S t o c k h o l m , S w e d e n 3 D e p a r t m e n t o f P s y c h i a t r y a n d P s y c h o l o g y , K a r o l i n s k a H o s p i t a l , S -1 0 4 0 1 S t o c k h o l m , S w e d e n 4 D e p a r t m e n t o f O r g a n i c C h e m i s t r y , U n i v e r s i t y o f U p p s a l a , Box 5 3 1 , S -7 5 1 2 1 U p p s a l a S w e d e n SUMMARY N o -c a r r i e r -a d d e d l 1 C -n i t r o m e t h a n e h a s b e e n p r e p a r e d f r o m ' l C -m e t h y l i o d i d e i n a o n e -p o t r e a c t i o n b y u s e o f s i l v e r o r s o d i u m n i t r i t e i n d i f f e r e n t s o l v e n t s . A c o n v e r s i o n o f u p t o 87% was o b t a i n e d w i t h i n 3 m i n . I t c o u l d e a s i l y b e d i s t i l l e d from h i g h -b o i l i n g s o l v e n t s t o a n o t h e r r e a c t i o n v e s s e l (14OoC, 3 m i n ) . I t s p o t e n t i a l a s a r a d i o l a b e l i n g p r e c u r s o r i n c o n d e n s a t i o n s w i t h a l d e h y d e s was s h o w n i n t h e s y n t h e s i s o f l l C -B -n i t r o s t y r e n e ( 8 5 % c o n v e r s i o n a f t e r 3 -5 m i n ) . Key W o r d s : " C -n i t r o m e t h a n e , " C -n i t r o a l k a n e , 1 C -! 3 -n i t r o s t y r e n e i To whom c o r r e s p o n d e n c e s h o u l d b e a d d r e s s e d
(-)-Norepinephrine is the predominant neurotransmitter of the sympathetic innervation of the heart. Racemic norepinephrine was labelled with carbon-11 and injected i.v. into Cynomolgus monkeys. Five minutes after injection there was a more than tenfold higher radioactivity in the heart than in adjacent tissue. Pretreatment with the norepinephrine reuptake inhibitor desipramine reduced the uptake by more than 80%. The high specific uptake of racemic [11C]norepinephrine indicates that enantiomerically pure (-)-[11C]norepinephrine has promising potential for detailed mapping of the sympathetic innervation of the human myocardium.
The synthesis of D- and L-(1-11C)tyrosine, starting with 11C-cyanide, is reported. DL-(1-11C)Tyrosine was prepared by the Bücherer-Strecker reaction, from carrier added 11C-cyanide with an incorporation of 80% in 20 min. The isolation of the pure D- and L-amino acid isomers from the enantiomeric mixture was accomplished within 15 min by preparative HPLC using a chiral stationary phase and a phosphate buffer as the mobile phase. Typically, the total synthesis time was 50 min (including purification) from end of trapping of 11C-cyanide, with a radiochemical yield of D- and L-amino acid of 40%-60%. The D- and L-(1-11C)tyrosine were both obtained optically pure, with a carrier added specific activity of 0.3-0.5 Ci/mmol and a radiochemical purity better than 99%. The 11C labelled L-tyrosine was used in an in vivo study in the human brain using positron emission tomography (PET).
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