Topical beta-blockers are commonly used for the management of primary open angle glaucoma (POAG). One of the rare but serious side effects of the topical beta-blockers is bradycardia, defined as a heart rate below 60 beats per minute. In few cases, the heart rate drops to much lower level resulting in syncope or symptomatic bradycardia. Topical beta-blockers are still widely used for POAG even though there are much better medications available. We present a series of four cases of symptomatic bradycardia resulting from the use of timolol eye drops and after discontinuation of the eye drops, heart rate improved to normal range (60-100 beats per minute).
INTRODUCTION: Bullous Pemphigoid lesions are a rare complication of Tenofovir therapy. It is proposed that this is caused by antibody formation, resulting in acantholysis, similar to idiopathic pemphigus. Reference #1: Lichenoid drug eruption to tenofovir in an HIV/hepatitis B virus co-infected patient.
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