Dermatitis atopik adalah penyakit inflamasi kronis dengan prevalensi tinggi pada anak yang terus meningkat di seluruh dunia. Dermatitis atopik merupakan penyakit multifaktor yang mencakup faktor genetik, pajanan infeksi, pajanan makanan, alergen dan lingkungan. Pruritus berulang yang dialami oleh pasien dermatitis atopik dapat menurunkan kualitas hidup dan dapat menjadi masalah yang serius. Hingga saat ini steroid masih menjadi terapi utama bagi pasien dermatitis atopik, baik pada anak maupun dewasa. Namun mengingat banyaknya efek samping yang ditimbulkan akibat pemberian steroid jangka panjang, alternatif terapi lain terus dicari. Peningkatan insidens dermatitis atopik yang bermakna secara global telah mengubah fokus riset para peneliti dalam pencegahan dan penanganan dermatitis atopik. Salah satu upaya pencegahan dermatitis atopik pada anak yang dianggap menjanjikan adalah pemberian suplementasi probiotik pada masa kehamilan. Beberapa penelitian memberikan hasil yang positif dalam menurunkan risiko dermatitis atopik melalui pemberian suplementasi probiotik saat hamil. Namun berbagai faktor, misalnya jenis probiotik yang digunakan, waktu pemberian, durasi pajanan probiotik dan dosis pemberian juga penting untuk diteliti lebih lanjut. Kata kunci: probiotik, dermatitis atopik, pencegahan, alergi
Background: Chronic heart failure (CHF) patients can fall into cardiac cachexia (CC), which is marked by the decrease of muscle mass and strength. Cardiac cachexia decreases the functional capacity and quality of life also increases the length of stay, medical fees, complications, and mortality rate. Branched-chain amino acid (BCAA) accounted for 35% of amino acids that build the muscle. We hope that BCAA supplementation can increase muscle strength of CHF patients, especially the elderly who is more prone to fall into CC. Thus, we performed an evidence-based case report to seek an opportunity of BCAA supplementation to an elderly with CHF.Objectives: To determine the efficacy of BCAA supplementation on increasing muscle strength in CHF patients.Methods: Literature searching of the evidence-based case report was performed on Pubmed, Cochrane, and Scopus according to the clinical query. Screening on title, abstract, and full text was done based on eligibility criteria (meta-analysis or clinical trials, suitability to clinical questions, English language, full-text availability, and human studies), followed by duplication filter and critical appraisal.Results: A randomized-controlled trial was found, but it didn’t find a significant difference between the experimental and control groups.Conclusions: BCAA supplementation doesn’t give a significant improvement in muscle strength in CHF patients.
Background and Objectives:Chronic low-grade inflammation has emerged as important pathophysiology of non-communicable diseases, which can cause negative effects to mother and baby. Dietary intake has been known as important factor to affect inflammation, which can be measured by high-sensitivity C-reactive protein (hs-CRP). This study aimed to examine the correlation between serum hs-CRP with dietary intake in lactating mothers.Methods:A cross-sectional study was conducted by consecutively enrolling 71 lactating mothers, 3-6 months post-partum, age 20-35 years old, visiting Grogol Petamburan and Cilincing community health center between February and April 2019. Dietary assessment was conducted using semi-quantitative food frequency questionnaire. Anthropometric measurements included were pre-pregnancy weight, post-partum weight, and body height. Serum hs-CRP was measured by immunoturbidimetry method. Spearman correlation was used, with p<0.05 considered significant.Results:Correlation was found between serum hs-CRP and energy (r = 0.372, p = 0.001), carbohydrate (r = 0.295, p = 0.013), and vitamin B6 (r = -0.285, p = 0.016) intake. We also found that serum hs-CRP was correlated with pre-pregnancy (r = 0.296, p = 0.012) and post-partum BMI (r = 0.430, p<0.001).Conclusion:Energy, carbohydrate, and vitamin B6 intakes are positively correlated with serum hs-CRP level.
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