Abstract‘Staggering disease’ is a neurological disease entity considered a threat to European domestic cats (Felis catus) for almost five decades. However, its aetiology has remained obscure. Rustrela virus (RusV), a relative of rubella virus, has recently been shown to be associated with encephalitis in a broad range of mammalian hosts. Here, we report the detection of RusV RNA and antigen by metagenomic sequencing, RT-qPCR, in-situ hybridization and immunohistochemistry in brain tissues of 27 out of 29 cats with non-suppurative meningoencephalomyelitis and clinical signs compatible with’staggering disease’ from Sweden, Austria, and Germany, but not in non-affected control cats. Screening of possible reservoir hosts in Sweden revealed RusV infection in wood mice (Apodemus sylvaticus). Our work indicates that RusV is the long-sought cause of feline ‘staggering disease’. Given its reported broad host spectrum and considerable geographic range, RusV may be the aetiological agent of neuropathologies in further mammals, possibly even including humans.

No abstract

No abstract

Septicaemia caused by the vancomycin-resistant Gram-positive bacteria Leuconostoc spp. is uncommon. We report a case of Leuconostoc spp. septicaemia in a child with short bowel syndrome fed through a central venous catheter and a gastrostomy. Leuconostoc spp. were isolated from several blood cultures. Despite several courses of antibiotics the fever continued and her condition deteriorated. After removal of the thrombotized central venous catheter her condition improved. Leuconostoc spp. was isolated from the thrombotic masses.

No abstract