Migraine patients often report intolerance to odours. Migraineurs report odours may trigger attacks, that they experience osmophobia during attacks, and olfactory hypersensitivity between attacks. In this paper we discuss olfactory mechanisms in migraine. We also present data from a pilot questionnaire study in a group of young women diagnosed with migraine. The study results confirm that hypersensitivity to odour is a common feature in women with migraine. Migraine pathophysiology likely explains this particular vulnerability. We discuss these pathophysiologic mechanisms and hypotheses relating odour intolerances and migraine.

Eclogites, blueschists and greenschists are found in close proximity to one another along a 1-km coastal section where the Cyclades Blueschist Unit (CBU) is exposed on SE Syros, Greece. Here, we show that the eclogites and blueschists experienced the same metamorphic history: prograde lawsonite blueschist facies metamorphism at 1.2-1.9 GPa and 410-530°C followed, at 43-38 Ma, by peak blueschist/eclogite facies metamorphism at 1.5-2.1 GPa and 520-580°C. We explain co-existence of eclogites and blueschists by compositional variation probably reflecting original compositional layering. It is also shown that the greenschists record retrogression at 0.34 ± 0.21 GPa and T = 456 ± 68°C. This was spatially associated with a shear zone on a scales of 10-100-m and veins on a scale of 1-10-cm. Greenschist facies metamorphism ended at (or shortly after) 27 Ma. We thus infer a period of metamorphic quiescence after eclogite/blueschist facies metamorphism and before greenschist facies retrogression which lasted up to 11-16 million years. We suggest that this reflects an absence of metamorphic fluid flow at that time and conclude that greenschist facies retrogression only occurred when and where metamorphic fluids were present. From a tectonic perspective, our findings are consistent with studies showing that the CBU is (a) a high-P nappe stack consisting of belts in which high-P metamorphism and exhumation occurred at different times and (b) affected by greenschist facies metamorphism during the Oligocene, prior to the onset of regional tectonic extension. K E Y W O R D Sbulk composition, Cyclades Blueschist Unit, HP-LT metamorphism, metamorphic fluids, Syros

Symptoms after inflammatory activation, so-called sickness behaviour, overlap with trans-diagnostic complaints. As no self-report questionnaire to assess sickness behaviour exists, we aimed to develop such an instrument, the Sickness Questionnaire. Items responsive to experimentally induced inflammatory activation (randomized double-blind study endotoxin (0.6 ng/kg) versus placebo, n = 52) were selected and the statistical properties were examined in 172 primary care patients. A principal component analysis indicated a one-factor solution (Cronbach's alpha = .86). This 10-item scale correlated with depression ( β = .41, p < .001), anxiety ( β = .36, p < .001), self-rated health ( β = .28, p < .001) and a single item of feeling sick ( β = .55, p < .001). The results support the adequacy of Sickness Questionnaire as a brief assessment instrument of perceived sickness behaviour.

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