Summary
Pure khellinin, m.pt. 175° to 176°C., possesses a persistent, rather selective stimulant action on the heart producing a more complete systole and a more complete diastole with a corresponding increase in cardiac output. It raises blood pressure. The glycoside is active and doses of 1 to 1ṁ5 mg./kg. of dog by intravenous injection. It increases the coronary flow, and is non-cumulative. Pure visammin, m.pt. 153° to 154°C., depresses the heart, producing principally a less complete systole with diminished cardiac output. The drug is active in doses of 2 to 4 mg./kg. of dog by intravenous injection. It increases the coronary flow. The impurities present in crude samples of khellinin or of visammin influence to an appreciable degree the normal response of the heart to the pure products.
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