The entitled organocatalyst is non‐toxic, cheap, bio‐degradable and easy to handle, and is used in the synthesis of pyran‐annulated heterocycles for the first time.
Magnetically separable cobalt ferrite nanoparticles (CoFe 2 O 4 , NPS) have been demonstrated for the first time as an efficient catalyst in Petasis-Borono-Mannich (PBM) reaction between salicylaldehydes, sec.amines and aryl boronic acids to furnish alkylaminophenols in high yields. Relatively shorter reaction times, easy purification of the products and reusability of the catalyst for five consecutive runs without appreciable loss in it's activity are the noteworthy features of the developed protocol.a Reaction conditions: salicylaldehyde (1 mmol), piperidine (1.2 mmol), phenyl boronic acid (1.2 mmol), acetonitrile (5 mL), catalyst. b Isolated yield. c Using water (5 mL) as the reaction medium.This journal is
Diethylamine has been demonstrated to be an efficient organocatalyst in the diastereoselective synthesis of Bcl-2 protein antagonist (HA-14-1) and of its structural analogues by one-pot condensation between salicylaldehyde and three different C-H acids, viz. ethyl cyanoacetate, phenylsulfonyl acetonitrile, and malononitrile. Easy commercial availability of the catalyst at extremely low cost and avoidance of conventional work-up as well as purification procedures qualifies this scalable protocol for a ''near-ideal synthesis''.
A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for "green synthesis."
A problem
solving, environmentally benign, and diversity oriented protocol has
been described for multicomponent synthesis of medicinally privileged
2-amino-3-phenyl (or methyl) sulfonyl-4H-chromenes
by one-pot, three component condensation among aldehydes, phenyl (or
methyl) sulphonyl acetonitrile, and α-naphthol, 3-dimethylamino
phenol, 4-hydroxy-N-methyl-quinoline-2-one as well
as 4-hydroxycarbazole, using diethylamine as an efficient organo catalyst.
The catalyst employed is commercially available, inexpensive, and
nontoxic. Ambient reaction conditions, very high yields, wide scope,
and avoidance of conventional isolation as well as chromatographic
purification have improved the practical utility of this protocol
manifold.
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