Intra-hospital mortality in cirrhotic patients is variable depending on the studies reported in literature. Several studies have demonstrated independent predictors of mortality. The aim of this work is indeed to identify these predictors. Patients and Methods: We conducted a retrospective study of 1080 cirrhotic patients hospitalized in our department of gastroenterology and hepatology between January 2001 and August 2010. A descriptive study of the study population was performed, and a univariate analysis looking for an association between intra-hospital mortality, and clinical, biological, etiological and socio-demographic characteristics of our patients. Results: The average age of our patients was 54 years, with an equal number of men and women. 41.1% of patients had cirrhosis secondary to hepatitis C and 18.5% had cirrhosis secondary to hepatitis B. 26.1% of our patients were CHILD C. Intra-hospital mortality was 8.7% (97 deaths) with a mean of 23.4 ± 35.8 months. Univariate analysis showed that the intra-hospital mortality was significantly associated with higher age (p = 0.049) as well as the reasons for admissions like hepatic encephalopathy, and hematemesis (p < 0.0001), melena, jaundice and ascites (p = 0.001). Among the biological parameters analyzed in univariate analysis, significant associations with mortality were objectified for high white blood cell count (p = 0.035), and high serum bilirubin and creatinine (p < 0.0001); low rate of prothrombin time (PT) (p < 0.0001), of albumin (p = 0.0001) and of serum sodium (p < 0.0001). Among the complications analyzed, significant associations with mortality were objectified for jaundice, ascites (p = 0.001), hemorrhagic decompensation, hepatic encephalopathy, and spontaneous bacterial peritonitis (p < 0.001). Univariate analysis of the etiology of cirrhosis objectified significant associations for cirrhosis secondary to hepatitis B (p = 0.001) and hepatitis C (p = 0.022). Multivariate analysis objectified four independent predictors of mortality: hepatic encephalopathy, infection (hyper leukocytosis ≥ 10,000/mm 3 ), renal failure (serum creatinine ≥ 15 mg/l) and hyponatremia. Conclusion: In our series, we identified four independent predictors of intra-hospital mortality in cirrhotic patients: hepatic encephalopathy, infection, renal failure and hyponatremia.

Objectif : L'hémorragie digestive haute (HDH) est une urgence fréquente en hépatogastroentérologie. Le profil épidémiologique des HDH reste mal connu dans notre pays. Le but de notre travail est de décrire le profil épidémio-logique, étiologique et évolutif des HDH et d'analyser les différents facteurs liés à la mortalité. Matériels et méthodes : Il s'agit d'une étude initialement rétrospective [2001][2002][2003][2004] puis prospective [2005][2006][2007][2008], ayant inclus tous les patients adultes qui se sont présentés pour une HDH et ayant bénéficié d'une endoscopie haute au centre hospitalier universitaire Hassan-II de Fès. Résultats : Mille trois cent trois cas ont été inclus. Huit cent vingt-sept étaient des hommes représentant 63,5 % des patients. L'âge moyen des patients était de 47,6 ± 17,7 ans. Les étiologies les plus fréquentes étaient l'hémorragie ulcéreuse (46 %) et l'hémorragie liée à l'HTP (23,3 %). La prévalence des oesophagites était de 10,9 % et celle des gastrites aiguës de 7,3 %. Les taux de récidive précoce et de mortalité intrahospitalière étaient de 8,3 et 6,5 % respectivement. Les hémorragies liées à l'HTP ou à la pathologie tumorale, l'âge avancé, l'état de choc initial et la récidive hémorragique sont les principaux facteurs de risque de mortalité retrouvés dans notre étude.Conclusion : Les patients de notre série avaient un âge jeune. La première étiologie des HDH dans notre contexte était la pathologie ulcéreuse reflétant la prévalence de celle-ci dans notre population. Les hémorragies liées à l'hypertension portale, l'âge avancé et la récidive hémorragique étaient les principaux facteurs liés à la mortalité. Pour citer cette revue : Acta Endosc. 41 (2011). Mots clésHémorragie digestive haute · Épidémiologie · Mortalité · Endoscopie · Ulcère gastroduodénal · Hypertension portale Abstract Background: Acute upper gastrointestinal bleeding (AUGIB) is a common emergency in hepatogastroenterology. Epidemiology of AUGIB in our country remains unknown. The aim of this study is to evaluate the clinical and etiological characteristics and outcomes of patients with upper gastrointestinal bleeding and to define risk factors of poor prognosis. Materials and methods: This is a retrospective (2001)(2002)(2003)(2004) and prospective (2005)(2006)(2007)(2008) study, including patients with AUGIB who had upper digestive endoscopy in Hassan II University Hospital of Fez. Results: Thousand three hundred and three cases were included. Eight hundred and twenty-seven were men (63.5%). The mean age was 47.6 ± 17.7 years. The most common causes of AUGIB were ulcer bleeding (46%) and bleeding related to portal hypertension (PH) (23.3%). Prevalence of esophagitis and acute gastritis were 10.9% and 7.3% respectively. The recurrence rate and in-hospital mortality were 8.3% and 6.5% respectively. Portal hypertension-related bleeding, malignancy, advanced age, shock and recurrent bleeding were the main risk factors of mortality in our study. bleeding, which reflects the prevalence of peptic ulcer in our population. ...

The upper gastrointestinal bleeding from esophageal or gastric varices is the most dangerous complication of portal hypertension. The purpose of this study was to identify the predictors of early rebleeding and mortality after a bleeding episode. Patients and Methods: It was a retrospective study including 215 patients admitted in our department of hepatology and gastroenterology at the Hassan II University Hospital of Fez, from January 2001 to January 2010. Results: The mean age of our patients was 51 years. Thirty percent of patients had cirrhosis due to virus (B or C). The majority of patients (79%) had only esophageal varices. Fifty patients (23%) had a bleeding recurrence. Twenty-five patients (11.5%) died during the first ten days, of which 52% had presented rebleeding (p = 0.01). In 30% of cases, the rebleeding was secondary to a fall of pressure ulcers. Univariate analysis showed that early mortality of patients was significantly associated with advanced age (p = 0.018), low prothrombin time (PT) (p = 0.022), low serum sodium (p = 0.03), low platelet count (p = 0.05), and elevated transaminases (p = 0.02). Conclusion: The survival of cirrhotic patients after a bleeding episode was influenced by advanced age, a low rate of PT, of serum sodium, and of the platelet count, and elevated transaminases.

No abstract

No abstract