The asymmetric alkynylation of aliphatic and aromatic aldehydes with propiolates was mediated by dialkylzinc and a novel prolinol catalyst without high reagent loading and any additives, such as Ti(Oi-Pr)(4), to give the corresponding γ-hydroxy-α,β-acetylenic esters with high enantiomeric excess of up to 95%.
Loading and any Additives. -A novel prolinol catalyst is used for the asymmetric alkynylation of aliphatic and aromatic aldehydes with propiolates mediated by dialkylzinc. -(KOJIMA*, N.; NISHIJIMA, S.; TSUGE, K.; TANAKA*, T.; Org. Biomol. Chem. 9 (2011) 12, 4425-4428, http://dx.doi.org/10.1039/c1ob05489a ; Grad. Sch. Pharm. Sci., Osaka Univ., Suita, Osaka 565, Japan; Eng.) -S. Adam 43-073
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