Purpose Fertility preservation is an important issue for young cancer patients. Random‐start controlled ovarian stimulation and double ovarian stimulation have been proposed for efficient oocyte retrieval within the limited time before cancer therapy. We aimed to clarify the efficacy of these new protocols within the Japanese population. Methods We performed a retrospective observational study at a multicenter from February 2012 to August 2017. The study entailed 50 cycles with 34 patients who underwent fertility preservation due to breast cancer. Follicular phase or luteal phase ovarian stimulation with aromatase inhibitor was performed. A second ovarian stimulation was started with or without waiting until the next menstruation. We measured the number of retrieved oocytes and cryopreserved oocytes/embryos, the ratio of mature oocytes, and the fertilization rate. Results The numbers of retrieved oocytes and frozen oocytes/embryos were not significantly different between follicular phase and luteal phase ovarian stimulation. The number of retrieved oocytes was not reduced at the second ovum pick up compared to the first ovum pick up in the double ovarian stimulation. Conclusions Random‐start controlled ovarian stimulation and double ovarian stimulation with aromatase inhibitor for breast cancer patients were effective protocols for retrieving a greater number of oocytes within the limited time.
目的:地域在住高齢者の体力の推移をパフォーマンステストにより把握し,新型コロナウイルス感染症流行下で は平時より顕著な体力低下が生じているのかを明らかにする.方法:2016 年から 2020 年にかけて開催された健 診事業に参加した地域在住高齢者 240 人(男性 107 人,女性 133 人,平均 76.7±5.1 歳)を対象とした.握力(上 肢筋力) ,開眼片足立ち時間(静的バランス能力) ,長座体前屈(柔軟性) ,Timed up and go test(TUG,複合的 移動能力) ,5 m 通常歩行時間(歩行能力) ,48 本ペグ移動(手指巧緻動作)を評価した.線形混合効果モデルを 用い,繰り返し測定データ(レベル 1) ,流行前(2016-2019 年)と流行下(2019-2020 年) (レベル 2) ,個人(レ ベル 3)の階層性を持つデータとして扱った.調査年(レベル 1)の固定効果を求めるとともに,調査年と流行 前・下(レベル 2)のクロス水準交互作用を確認し,2019 年から 2020 年にかけての追加の低下幅(B)を推定し た.結果:有意なクロス水準交互作用が確認された項目は,男性で長座体前屈(B=−2.56,95% 信頼区間: −4.45-−0.66 cm) ,TUG(+0.39,0.21-0.56 秒) ,5 m 通常歩行時間(+0.15,0.04-0.27 秒)であった.女性 では開眼片足立ちを除くすべての項目である,握力(−0.58,−1.11-−0.05 kg) ,長座体前屈(−3.53,−5.11-−1.95 cm) ,TUG(+0.15,0.03-0.27 秒) ,5 m 通常歩行時間(+0.14,0.04-0.24 秒) ,48 本ペグ移動(+0.89, 0.28-1.51 秒)であった.結論:男女いずれも柔軟性や移動動作能力の低下が確認されたことに加えて,女性で のみ上肢筋力や手指巧緻動作が低下していた.
[Purpose] In this study, we aimed to analyze customer satisfaction as a tool to investigate the association among happiness, health status, and well-being using the Happiness & Health Feeling Scale. [Participants and Methods] We included 17 elderly participants and measured the happiness and health statuses using the Happiness & Health Feeling Scale. We analyzed customer satisfaction by correlating subjective well-being with the questionnaire scores. [Results] The results showed a negative correlation between subjective well-being and the score on each questionnaire (correlation coefficient= −0.476). The elderly participants showed lower scores associated with self-esteem, including external appreciation and self-love, whereas high scores associated with eating and pleasure. The Cronbach’s alpha was 0.814. [Conclusion] This study showed an inverse correlation between Happiness & Health Feeling Scale score and well-being, presumably because of low scores associated with self-esteem, which should be prioritized for improvement. The additional use of customer satisfaction analysis using the Happiness & Health Feeling Scale could be helpful to elucidate the subjective association between happiness and health-related factors.
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