Kaori Shinmyouzu scite author profile

Kaori Shinmyouzu

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43Citation Statements Received

70Citation Statements Given

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RIKEN Center for Computational Science

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Mediator Complex Recruits Epigenetic Regulators via Its Two Cyclin-dependent Kinase Subunits to Repress Transcription of Immune Response Genes

Tsutsui

Fukasawa

Shinmyouzu

et al. 2013

Journal of Biological Chemistry

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Background: Two CDK subunits of the Mediator complex play pivotal roles in transcription by a mechanism that has not yet been elucidated. Results: The histone arginine methyltransferase PRMT5 is a Mediator CDK-interacting protein. Conclusion:Mediator-associated PRMT5 symmetrically dimethylates histone H4 arginine 3, and this might cause transcriptional repression. Significance: This work enables further exploration of Mediator functions in transcriptional repression.

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