Coumarins and its analogues have been widely used as chromophore in design of fluorescent probe, while less coumarin-based fluorescent probe was reported for detection of anion in water. In this article, coumarin-based fluorescent probes with salicylaldehyde functionality as recognition unit have been developed for selective detection of bisulfite anions in water. Four novel fluorescent probes were synthesized from 4-haloresorcinol in three steps. The chemoprobe exhibited selective response to bisulfite over other anions. Moreover, the detection mechanism was studied. Upon bisulfite added, the fluorescent intensity of the probes was enhanced highly due to the nucleophilic addition reaction of formyl group with bisulfite anion.
A coumarin-based fluorescent chemosensor 1 for Zn(2+) was designed and synthesized. Compound 1 exhibits lower background fluorescence due to intramolecular photoinduced electron transfer. However, upon mixing with Zn(2+) in 30% (v/v) aqueous ethanol, a "turn-on" fluorescence emission is observed. The fluorescence emission increases linearly with Zn(2+) concentration in the range 0.5-10 micromol L(-1) with a detection limit of 0.29 micromol L(-1). No remarkable emission enhancement was, however, observed for other metal ions. The proposed chemosensor was applied to the determination of Zn(2+) in water samples with satisfactory results.
The one-carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. Bisbenzimidazolium salts were used as a tetrahydrofolate coenzyme model, and thus the biomimetic synthesis of twenty-four acyclic diketones as precursors for macrocyclic ketones was successfully accomplished by using the addition-hydrolysis reaction of the bisbenzimidazolium salts with alkyl magnesium halide, wherein six diketones have not been reported in literature. Accordingly, a short route to muscone analogues was provided.
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