Synthesis of Optically Active N-Protected α-Aminoketones and α-Amino Alcohols. -An efficient method for the synthesis of chiral N-protected α-aminoketones [cf. (V), (IX)] based on the Grignard reaction of corresponding Weinreb amides (III) or (VIII), resp., and their subsequent reduction furnishing corresponding amino alcohols are described. -(ZHOU*, Z. H.; TANG, Y. L.; LI, K. Y.; LIU, B.; TANG, C. C.; Heteroat.
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