Industrial-scale synthesis of eldecalcitol is described. AA highly diastereoselective epoxidation of p-methoxybenzyl (PMB) protected dienol at room temperature provides the key epoxide intermediate with a secondary hydroxyl group, which is alkylated with a triflate to set up all of the subunits at the C-1, C-2, and C-3 positions of the A-ring fragment. Selective protecting group manipulation followed by palladium-catalyzed cyclization then provides the A-ring synthon. The C/D-ring fragment is obtained by (1) direct C-H hydroxylation of Grundman's ketone using in situ prepared trifluoropropanone dioxirane and (2) protection. Finally, the coupling of the A-ring with the C/D-ring fragment, global deprotection, and recrystallization provide the highly crystalline eldecalcitol.
In this paper, we used a robot operating system (ROS) that is designed to work with mobile robots. ROS provides us with simultaneous localization and mapping of the environment, and here it is used to autonomously navigate a mobile robot simulator between specified points. Also, when the mobile robot automatically navigates between the starting point and the target point, it bypasses obstacles; and if necessary, sets a new path of the route to reach the goal point.
Nowadays, augmented reality is becoming more and more popular because it can help individuals learn about many things, such as buildings, books, historical places, etc. in real time. The Myers–Briggs Type Indicator (MBTI) test, a questionnaire-based test, is used to determine personality type, which influences perceptions of the world and the ways in which individuals make decisions. This system is based on C.G Jung’s typological theory and was developed by Katherine and Isabel Briggs. The purpose of this paper is to use the MBTI personality test to define the personality types of users. To accomplish this aim, we used Unity3D, Processing, and Vuforia SDK. First, the processing program was used to produce results from sixteen images and send them to Unity3D. Second, Vuforia SDK was used to recognize masks in real time and map images to the masks. Then, Unity3D displayed the final mapping result.
Modern people can use navigation on the outside to save time and get to the destination well. Likewise, in order to find out more information about a destination building, such a system is increasingly needed both in front of the computer (on-line) of the house and after reaching the destination in the building (off-line). Accordingly, we employ Building Information System (BIS) as a system that provide users with content related to a building like BIO and BIM. The Building Information Online system (BIO) is an interactive map application designed to assist customers in finding parcels and building on a map online. The Building Information Modeling (BIM) allows nD information to be visualized simultaneously by architects, engineers and constructors to gain a synchronized understanding viewing from different perspectives. Inspired by above researches, we implement a service that provides online and offline Virtual Reality (VR) and Augmented Reality (AR) content for a building. This system can provide users outside the building with information within the building via devices with VR and AR support regardless of space restrictions. The system is designed to operate across scenarios requiring offline, online, offline-online collaboration, etc., and the corresponding experiments are carried out.
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